Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
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Potential of Glutamate-Based Drug Discovery for Next Generation AntidepressantsCurrent investigational drugs for major depressionEmerging targets for antidepressant therapiesInfluence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autismAdvances in the treatment of anxiety: targeting glutamate.Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP.On the mechanism of the antidepressant-like action of group II mGlu receptor antagonist, MGS0039.The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.Advances in the treatment of depressionMetabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEPReduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study.Future prospects in depression researchTherapeutic potential of metabotropic glutamate receptor modulators.Innovative approaches for the development of antidepressant drugs: current and future strategiesAre compounds acting at metabotropic glutamate receptors the answer to treating depression?Emerging treatments for depression.Reduced metabotropic glutamate receptor 5 in the Flinders Sensitive Line of rats, an animal model of depression: an autoradiographic study.Amygdalar activation of group I metabotropic glutamate receptors produces anti- and pro-conflict effects depending upon animal sex in a sexually dimorphic conditioned conflict-based anxiety model.The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related DisordersCharacterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [¹¹C]ABP688Metabotropic glutamate receptor subtype 5 antagonism in learning and memory.Investigational NMDA receptor modulators for depression.Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents.Tyrosine phosphorylation of glutamate receptors by non-receptor tyrosine kinases: roles in depression-like behavior.Glutamate-Based Drug Discovery for Novel Antidepressants.Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.In vivo positron emission tomography imaging with [¹¹C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons.In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling.mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior.Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease.Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model.The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y.Preclinical evaluation and test-retest studies of [(18)F]PSS232, a novel radioligand for targeting metabotropic glutamate receptor 5 (mGlu5).Improved Syntheses of the Mglu₅ Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling.Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria.
P2860
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P2860
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
description
2002 nî lūn-bûn
@nan
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@ast
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@en
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@nl
type
label
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@ast
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@en
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@nl
prefLabel
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@ast
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@en
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@nl
P2093
P50
P1433
P1476
Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.
@en
P2093
A Kłodzińska
E Chojnacka-Wójcik
E Tatarczyńska
P304
P356
10.1016/S0028-3908(02)00082-5
P577
2002-08-01T00:00:00Z