The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.
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Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapsesGroup 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and diseaseFluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in ratsMetabotropic glutamate receptors: from the workbench to the bedside.MGluR5 mediates the interaction between late-LTP, network activity, and learningPrenatal restraint stress generates two distinct behavioral and neurochemical profiles in male and female rats.Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learningCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways.The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues.A novel non-CB1/TRPV1 endocannabinoid-mediated mechanism depresses excitatory synapses on hippocampal CA1 interneuronsSelective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade.Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.Extracellular recordings of rodents in vivo: their contribution to integrative neuroscience.Metabotropic glutamate receptor ligands as potential therapeutics for addictionMetabotropic glutamate receptor subtype 5 antagonism in learning and memory.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Group 1 metabotropic glutamate receptor function and its regulation of learning and memory in the aging brainGlutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.Hippocampal metabotropic glutamate receptor long-term depression in health and disease: focus on mitogen-activated protein kinase pathways.Molecular and cellular aspects of age-related cognitive decline and Alzheimer's disease.The Role of mGlu Receptors in Hippocampal Plasticity Deficits in Neurological and Psychiatric Disorders: Implications for Allosteric Modulators as Novel Therapeutic Strategies.The 5-hydroxytryptamine4 receptor enables differentiation of informational content and encoding in the hippocampus.Strain-dependent variations in spatial learning and in hippocampal synaptic plasticity in the dentate gyrus of freely behaving rats.Relationship of hippocampal theta and gamma oscillations to potentiation of synaptic transmission.The temporoammonic input to the hippocampal CA1 region displays distinctly different synaptic plasticity compared to the Schaffer collateral input in vivo: significance for synaptic information processing.Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation.Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses.Place field stability requires the metabotropic glutamate receptor, mGlu5.The metabotropic glutamate receptor, mGlu5, is required for extinction learning that occurs in the absence of a context change.Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease.Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses.Effects of the Positive Allosteric Modulator of Metabotropic Glutamate Receptor 5, VU-29, on Impairment of Novel Object Recognition Induced by Acute Ethanol and Ethanol Withdrawal in Rats.Environmental enrichment improves hippocampal function in aged rats by enhancing learning and memory, LTP, and mGluR5-Homer1c activity.Effects of common GRM5 genetic variants on cognition, hippocampal volume and mGluR5 protein levels in schizophrenia.Endogenous hippocampal LTD that is enabled by spatial object recognition requires activation of NMDA receptors and the metabotropic glutamate receptor, mGlu5.
P2860
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P2860
The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity.
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@ast
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@en
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@nl
type
label
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@ast
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@en
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@nl
prefLabel
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@ast
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@en
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@nl
P2860
P356
P1433
P1476
The metabotropic glutamate rec ...... ppocampal synaptic plasticity.
@en
P2093
Karl-Heinz Braunewell
P2860
P304
P356
10.1093/CERCOR/BHI047
P577
2005-02-09T00:00:00Z