Methylation of the KEAP1 gene promoter region in human colorectal cancer - Wikidata - awgldk - TriplyDB

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Methylation of the KEAP1 gene promoter region in human colorectal cancer

http://www.wikidata.org/entity/Q34156322

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Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Epigenetic regulation of Keap1-Nrf2 signaling The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer The complexity of the Nrf2 pathway: beyond the antioxidant response The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism Cytoprotection "gone astray": Nrf2 and its role in cancer Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer.Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2 Targeting nrf2 signaling to combat chemoresistance.Iron-ascorbate-mediated lipid peroxidation causes epigenetic changes in the antioxidant defense in intestinal epithelial cells: impact on inflammation Association of Nrf2 polymorphism haplotypes with acute lung injury phenotypes in inbred strains of mice.NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival.Epigenetic silencing BCL6B induced colorectal cancer proliferation and metastasis by inhibiting P53 signaling.Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts.Keap1 expression has independent prognostic value in pancreatic adenocarcinomas Functional Role of NRF2 in Cervical Carcinogenesis.Prognostic and predictive values of Nrf2, Keap1, p16 and E-cadherin expression in ovarian epithelial carcinoma.UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis Aberrant Keap1 methylation in breast cancer and association with clinicopathological features.TrkB Promotes Breast Cancer Metastasis via Suppression of Runx3 and Keap1 Expression Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.Gankyrin has an antioxidative role through the feedback regulation of Nrf2 in hepatocellular carcinoma.Genomic structure and variation of nuclear factor (erythroid-derived 2)-like 2 The emerging role of the Nrf2-Keap1 signaling pathway in cancer The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination Epigenetic regulation of DACH1, a novel Wnt signaling component in colorectal cancer Aldo-Keto Reductase AKR1C1-AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy.Monitoring Keap1-Nrf2 interactions in single live cells.Nrf2 activation as target to implement therapeutic treatments The role of Nrf2 and ATF2 in resistance to platinum-based chemotherapy.Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells.Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters.The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment.HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation.Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy.ROS-independent Nrf2 activation in prostate cancer

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Methylation of the KEAP1 gene promoter region in human colorectal cancer

http://www.wikidata.org/entity/Q34156322

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

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name

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@ast

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@en

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@nl

type

label

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@ast

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@en

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@nl

prefLabel

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@ast

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@en

Methylation of the KEAP1 gene promoter region in human colorectal cancer

@nl

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1471-2407-12-66

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Methylation of the KEAP1 gene promoter region in human colorectal cancer

@en

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Atsushi Ishiguro

http://www.w3.org/2001/XMLSchema#string

Hiroshi Kijima

http://www.w3.org/2001/XMLSchema#string

Jugoh Itoh

http://www.w3.org/2001/XMLSchema#string

Junsei Mimura

http://www.w3.org/2001/XMLSchema#string

Ken Itoh

http://www.w3.org/2001/XMLSchema#string

Naoyuki Hanada

http://www.w3.org/2001/XMLSchema#string

Qiliang Zhou

http://www.w3.org/2001/XMLSchema#string

Ruowen Sun

http://www.w3.org/2001/XMLSchema#string

Shinsaku Fukuda

http://www.w3.org/2001/XMLSchema#string

Takenori Takahata

http://www.w3.org/2001/XMLSchema#string

P2860

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Mechanistic studies of the Nrf2-Keap1 signaling pathway

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Cancer statistics, 2009

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1471-2407-12-66

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scholarly article

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10.1186/1471-2407-12-66

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12

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2012-02-13T00:00:00Z

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1021949502

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colorectal cancer

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3296656

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