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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

http://www.wikidata.org/entity/Q34163054

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Electron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial Bioenergetics Mitochondrial morphology-emerging role in bioenergetics PGC-1α, mitochondrial dysfunction, and Huntington's disease After the banquet: mitochondrial biogenesis, mitophagy, and cell survival Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases Shaping the role of mitochondria in the pathogenesis of Huntington's disease Mitochondrial dysfunction in neurodegenerative diseases Metabolism in HD: still a relevant mechanism?Inhibition of mitochondrial protein import by mutant huntingtin Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress Bax interacting factor-1 promotes survival and mitochondrial elongation in neurons Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys.PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models.Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases.D-β-hydroxybutyrate is protective in mouse models of Huntington's disease.Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.PGC-1α provides a transcriptional framework for synchronous neurotransmitter release from parvalbumin-positive interneurons.Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α Therapeutic approaches to preventing cell death in Huntington disease Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.Metabolic states following accumulation of intracellular aggregates: implications for neurodegenerative diseases.Autophagy-mediated turnover of dynamin-related protein 1.Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.Truncated peroxisome proliferator-activated receptor-γ coactivator 1α splice variant is severely altered in Huntington's disease Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease.Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease.Mitochondria: the next (neurode)generation miR-196a Ameliorates Cytotoxicity and Cellular Phenotype in Transgenic Huntington's Disease Monkey Neural Cells Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1.Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease.PINK1-induced mitophagy promotes neuroprotection in Huntington's disease Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

http://www.wikidata.org/entity/Q34163054

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

@zh-hant

2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

@en

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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type

label

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

@ast

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

@en

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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prefLabel

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

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Human Molecular Genetics

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

@en

P2093

Christina K Edgerly

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Jennifer P Moody

http://www.w3.org/2001/XMLSchema#string

Jinho Kim

http://www.w3.org/2001/XMLSchema#string

Karen Smith

http://www.w3.org/2001/XMLSchema#string

Kerry Cormier

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M Flint Beal

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Olivia L Bordiuk

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P2860

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

Dissection of the mitochondrial import and assembly pathway for human Tom40

OPA1 requires mitofusin 1 to promote mitochondrial fusion

A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia

Formation of molecular species of mitochondrial cardiolipin. 1. A novel transacylation mechanism to shuttle fatty acids between sn-1 and sn-2 positions of multiple phospholipid species

Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigrees

The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast

The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast.

Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p

Surfing the p53 network

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3919-3935

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scholarly article

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10.1093/HMG/DDQ306

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20

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19

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Robert J Ferrante

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2010-07-21T00:00:00Z

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45365717

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20660112

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Huntington disease

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2947400

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