Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice. - Wikidata - awgldk - TriplyDB

Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.

Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.

http://www.wikidata.org/entity/Q34166819

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Gap junction modulation and its implications for heart function Small G proteins in the cardiovascular system: physiological and pathological aspects The distinct conformational dynamics of K-Ras and H-Ras A59G RAS oncogenes: weaving a tumorigenic web Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.Ras oncogenes: split personalities Identifying mutation specific cancer pathways using a structurally resolved protein interaction network.Ras history: The saga continues.A comprehensive survey of Ras mutations in cancer.Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy.Activated Ras alters lens and corneal development through induction of distinct downstream targets.Both the C-terminal polylysine region and the farnesylation of K-RasB are important for its specific interaction with calmodulin The structural basis for cancer treatment decisions.Nras overexpression results in granulocytosis, T-cell expansion and early lethality in mice.Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus.Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells RAS transformation requires CUX1-dependent repair of oxidative DNA damage.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.Ras proteins: paradigms for compartmentalised and isoform-specific signalling.How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2 The genetics and biology of KRAS in lung cancer.Genetic analysis of Ras genes in epidermal development and tumorigenesis.Decoding RAS isoform and codon-specific signalling.The renewed battle against RAS-mutant cancers.The role of wild type RAS isoforms in cancer.The differential palmitoylation states of N-Ras and H-Ras determine their distinct Golgi subcompartment localizations.Absence of K-Ras Reduces Proliferation and Migration But Increases Extracellular Matrix Synthesis in Fibroblasts.Transcriptional networks of knockout cell lines identify functional specificities of H-Ras and N-Ras: significant involvement of N-Ras in biotic and defense responses.Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy.Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice Kras is Required for Adult Hematopoiesis.Quantification of spatiotemporal patterns of Ras isoform expression during development.

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Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.

http://www.wikidata.org/entity/Q34166819

description

2005 nî lūn-bûn

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2005 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2005 թվականի մայիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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SJ.EMBOR.7400397

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Replacement of K-Ras with H-Ra ...... cular pathology in adult mice.

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Andrea Affuso

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Annamaria Rosica

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Antonella Notte

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Assunta De Rienzo

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Lisa Bauer

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Mario De Felice

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Nicoletta Potenza

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Roberta Poulet

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Roberto Di Lauro

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P2860

Dysregulation of HSG triggers vascular proliferative disorders

Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling

Targeting RAS signalling pathways in cancer therapy

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms

Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis

An integrated regulatory network controlling survival and migration in thyroid organogenesis

Understanding Ras: 'it ain't over 'til it's over'.

Dynamic fatty acylation of p21N-ras.

Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development

Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists.

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10.1038/SJ.EMBOR.7400397

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5

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Gabriella De Vita

Carmine Vecchione

Giuseppe Cifelli

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2005-05-01T00:00:00Z

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7874495

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15864294

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Aparato circulatorio

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1299307

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