Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin.
about
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesionRac3-induced neuritogenesis requires binding to Neurabin IThe PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding moduleAsef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migrationRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseasePresynaptic spinophilin tunes neurexin signalling to control active zone architecture and functionHigh-resolution structure of the Tiam1 PHn-CC-Ex domainMechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapsesTiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neuronsCcpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor DbsSelective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabinTiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulationRap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activationDevelopmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREBp21-activated kinase regulates endothelial permeability through modulation of contractility.Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagenCdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatum.Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.Tiam1 gene expression and its significance in colorectal carcinoma.Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.Regulation of breast cancer cell motility by T-cell lymphoma invasion and metastasis-inducing protein.Regulation of Neuronal Function by Ras-GRF Exchange Factors.Control of synapse development and plasticity by Rho GTPase regulatory proteins.S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation.The role of Rho GTPase proteins in CNS neuronal migration.The guanine nucleotide exchange factor (GEF) Asef2 promotes dendritic spine formation via Rac activation and spinophilin-dependent targeting.The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells.Regulation of alpha2AR trafficking and signaling by interacting proteins.Cyclin-dependent Kinase 5 (Cdk5)-dependent Phosphorylation of p70 Ribosomal S6 Kinase 1 (S6K) Is Required for Dendritic Spine Morphogenesis.Regulation of the mTOR-Rac1 axis in platelet functionThe fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis.Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer
P2860
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P2860
Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@ast
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@en
Regulation of p70 S6 kinase by ...... ine nucleotide exchange factor
@nl
type
label
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@ast
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@en
Regulation of p70 S6 kinase by ...... ine nucleotide exchange factor
@nl
prefLabel
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@ast
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@en
Regulation of p70 S6 kinase by ...... ine nucleotide exchange factor
@nl
P2093
P2860
P356
P1476
Regulation of p70 S6 kinase by ...... and the scaffold spinophilin.
@en
P2093
Beth A Connolly
Larry A Feig
Rachel J Buchsbaum
P2860
P304
18833-18841
P356
10.1074/JBC.M207876200
P407
P577
2003-01-16T00:00:00Z