Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex.
about
Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of ActivationThe linker connecting the two kringles plays a key role in prothrombin activationExosite-driven substrate specificity and function in coagulationContribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase,Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.Prothrombin structure: unanticipated features and opportunities.Targeting exosites on blood coagulation proteases.Ixolaris binding to factor X reveals a precursor state of factor Xa heparin-binding exosite.Thrombomodulin allosterically modulates the activity of the anticoagulant thrombin.Zymogenic and enzymatic properties of the 70-80 loop mutants of factor X/XaExpression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complexHow the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of ProthrombinDeuterium solvent isotope effect and proton-inventory studies of factor Xa-catalyzed reactionsExosites in the substrate specificity of blood coagulation reactions.Membrane-dependent interaction of factor Xa and prothrombin with factor Va in the prothrombinase complex.HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase.A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.The Dual Regulatory Role of Amino Acids Leu480 and Gln481 of Prothrombin.The critical role of the 185-189-loop in the factor Xa interaction with Na+ and factor Va in the prothrombinase complex.Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase.The contribution of amino acid region ASP695-TYR698 of factor V to procofactor activation and factor Va function.Effects of activation peptide bond cleavage and fragment 2 interactions on the pathway of exosite I expression during activation of human prethrombin 1 to thrombin.Role of prothrombin fragment 1 in the pathway of regulatory exosite I formation during conversion of human prothrombin to thrombin.Proexosite-1-dependent recognition and activation of prothrombin by taipan venom.Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex.Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.Spellbinding Effects of the Acidic COOH-Terminus of Factor Va Heavy Chain on Prothrombinase Activity and Function.The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin.Role of the N-terminal epidermal growth factor-like domain of factor X/Xa.Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation.Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C.A control switch for prothrombinase: characterization of a hirudin-like pentapeptide from the COOH terminus of factor Va heavy chain that regulates the rate and pathway for prothrombin activation.The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII.Incorporation of factor Va into prothrombinase is required for coordinated cleavage of prothrombin by factor Xa.
P2860
Q27678654-5F8C7DD6-0217-4185-BEBB-20F62B3E52ECQ27683765-B73A5502-8B6D-4E2C-9699-50F2CF0524FDQ28301227-CEBA8B5D-4363-4363-B7A0-AE2C64197C04Q28749128-B7AD65DE-FC7D-4DE6-AF69-FC0D9C2DD1B8Q30501624-546FA9E0-6E61-42AC-B306-FE26211B98C9Q35033463-EEAF60AF-B676-4499-9A7D-ED9DF5527B63Q36128237-CBF642CF-D0C8-4757-8D58-C3C1AE58F0F5Q36281976-1A6185EA-5081-4063-83B9-91C5E1DB74D1Q36348107-4B40951B-AC94-4976-A22C-740E295DB05DQ36526481-86DF5DC5-0934-41A7-BA88-8274F135CF2FQ36538526-D1BE4671-08D2-4B12-8441-C0041294CBBEQ36737737-534E3F1B-A76D-4BA7-90E4-770BEF1A1C30Q36744837-D9F54B76-4E82-4CCB-ADF2-266232343B4AQ36874076-2B4872D7-85C7-447A-8FBD-EA37766ADD38Q36884329-593D13C9-6808-406A-B995-2D33186FA9C9Q37221258-ADD125D0-AA61-4FE7-859C-0E642D0AEFDCQ38308474-E556C6C3-8E94-498C-A3C7-064F98A0339BQ38327215-1144704D-9515-4F4C-93C2-38BCBE8BF729Q40280737-401BCBE4-F26D-423B-B2FF-29167A2290BDQ40519264-A47EF8E7-5012-4DF0-813B-71CD545B15D9Q41922890-9C96E123-09FB-43C1-BE02-C51E418C1971Q42610978-4966A23D-9FDE-470E-A337-94C8D2FD51DCQ44562077-9D83D970-168A-44B2-9F8A-7CC8542B915AQ44562081-89E8DBB2-E7F4-4D33-B334-A5208307814BQ44760449-226B2A6A-EC90-4270-8D0E-81E42E0B3CDEQ45032492-A2609B69-CC22-4840-837D-D9309ADCF563Q46806167-8879C70C-86A5-47A0-A84D-6DBF399B7CC5Q47158083-31982BEE-7D12-4A44-82F9-C3C20E288936Q47418397-3D2FD5E2-07CA-4BCE-A8EE-6D8AAB766E8FQ47739755-6BB87F5D-7FCB-4C65-A750-49F7E7238C0EQ47804160-1DF58F13-5CA1-4F45-A603-64253788BFCEQ51263915-7B36E72E-04FC-4813-BDCF-DFE8C454E3CFQ53425306-6926D563-64E2-40BB-904A-D8DD223F8E63Q53595426-2DD1ABFB-D300-43C6-B420-6EC7DD251489Q53626760-F6507FB5-A0FD-48A4-A14F-73BD308F95EFQ53675691-4262D466-BC59-4C24-8783-C4F310F6B5BB
P2860
Proexosite-1 on prothrombin is a factor Va-dependent recognition site for the prothrombinase complex.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Proexosite-1 on prothrombin is ...... or the prothrombinase complex.
@en
type
label
Proexosite-1 on prothrombin is ...... or the prothrombinase complex.
@en
prefLabel
Proexosite-1 on prothrombin is ...... or the prothrombinase complex.
@en
P2093
P2860
P356
P1476
Proexosite-1 on prothrombin is ...... or the prothrombinase complex.
@en
P2093
Alireza R Rezaie
Likui Yang
P2860
P304
27564-27569
P356
10.1074/JBC.M302707200
P407
P577
2003-05-14T00:00:00Z