P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage - Wikidata - awgldk - TriplyDB

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

http://www.wikidata.org/entity/Q34174808

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Traumatic Axonal Injury: Mechanisms and Translational Opportunities The molecular clock as a metabolic rheostat Increasing Adult Hippocampal Neurogenesis is Sufficient to Reduce Anxiety and Depression-Like Behaviors Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases Development and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal Reaction Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds Nuclear DNA damage signalling to mitochondria in ageing Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis P7C3 neuroprotective chemicals block axonal degeneration and preserve function after traumatic brain injury PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].Hope on the (fruit) fly: the Drosophila wing paradigm of axon injury.Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus An Aminopropyl Carbazole Derivative Induces Neurogenesis by Increasing Final Cell Division in Neural Stem Cells.SARM1 activation triggers axon degeneration locally via NAD⁺ destruction Interventions to Slow Aging in Humans: Are We Ready?Passage Variation of PC12 Cells Results in Inconsistent Susceptibility to Externally Induced Apoptosis.Novel targets for mitochondrial medicine.Enhancing NAD+ Salvage Pathway Reverts the Toxicity of Primary Astrocytes Expressing Amyotrophic Lateral Sclerosis-linked Mutant Superoxide Dismutase 1 (SOD1).Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase.Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.Imaging Redox State in Mouse Muscles of Different Ages.Recent developments and applications of clickable photoprobes in medicinal chemistry and chemical biology.Pyridine Dinucleotides from Molecules to Man.Nicotinamide Adenine Dinucleotide Metabolism and Neurodegeneration.P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo.Targeting Nicotinamide Phosphoribosyltransferase as a Potential Therapeutic Strategy to Restore Adult Neurogenesis.Acute Axonal Degeneration Drives Development of Cognitive, Motor, and Visual Deficits after Blast-Mediated Traumatic Brain Injury in Mice.Sirtuins, a promising target in slowing down the ageing process.The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons Does eating less make you live longer and better? An update on calorie restriction.Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy.Suppression of circadian secretion of glucagon-like peptide-1 by the saturated fatty acid, palmitate.Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.Neuroprotective Efficacy of an Aminopropyl Carbazole Derivative P7C3-A20 in Ischemic Stroke.DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP Model.

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P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage

http://www.wikidata.org/entity/Q34174808

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

@nl

type

label

P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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prefLabel

P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

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J.CELL.2014.07.040

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P1476

P7C3 neuroprotective chemicals ...... limiting enzyme in NAD salvage

@en

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Andrew A Pieper

http://www.w3.org/2001/XMLSchema#string

Deepak Nijhawan

http://www.w3.org/2001/XMLSchema#string

Gelin Wang

http://www.w3.org/2001/XMLSchema#string

Hamid Mirzaei

http://www.w3.org/2001/XMLSchema#string

Jacinth Naidoo

http://www.w3.org/2001/XMLSchema#string

Joseph M Ready

http://www.w3.org/2001/XMLSchema#string

Pano Theodoropoulos

http://www.w3.org/2001/XMLSchema#string

Sivaramakrishnan Yadavalli

http://www.w3.org/2001/XMLSchema#string

Steven L McKnight

http://www.w3.org/2001/XMLSchema#string

Ting Han

http://www.w3.org/2001/XMLSchema#string

P2860

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

Discovery of a proneurogenic, neuroprotective chemical

An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse

Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.

Click Chemistry: Diverse Chemical Function from a Few Good Reactions

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

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1324-1334

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scholarly article

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10.1016/J.CELL.2014.07.040

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6

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158

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2014-09-01T00:00:00Z

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265594411

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25215490

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4163014

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