Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.
about
Maraviroc: a review of its use in HIV infection and beyondStructural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usageToward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptorsStructural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico studyEstimation of 2Nes from temporal allele frequency data.The CCR5-antagonist Maraviroc reverses HIV-1 latency in vitro alone or in combination with the PKC-agonist Bryostatin-1ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs.Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity.Analysis of binding sites for the new small-molecule CCR5 antagonist TAK-220 on human CCR5.Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.In silico studies on DARC.The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitorsG protein-coupled receptors: in silico drug discovery in 3D.CD4 and CCR5 constitutively interact at the plasma membrane of living cells: a confocal fluorescence resonance energy transfer-based approach.Circular CCR5 peptide conjugates and uses thereof (WO2008074895).Adaptive Gene Loss? Tracing Back the Pseudogenization of the Rabbit CCL8 Chemokine.Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models.Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.Insights into the binding modes of CC chemokine receptor 4 (CCR4) inhibitors: a combined approach involving homology modelling, docking, and molecular dynamics simulation studies.Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens.Structural insight into the binding complex: β-arrestin/CCR5 complex.Computational modeling of human coreceptor CCR5 antagonist as a HIV-1 entry inhibitor: using an integrated homology modeling, docking, and membrane molecular dynamics simulation analysis approach.Impact of chemokines CCR5∆32, CXCL12G801A, and CXCR2C1208T on bladder cancer susceptibility in north Indian population.
P2860
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P2860
Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structure modeling of the chem ...... igand binding and selectivity.
@ast
Structure modeling of the chem ...... igand binding and selectivity.
@en
Structure modeling of the chem ...... igand binding and selectivity.
@nl
type
label
Structure modeling of the chem ...... igand binding and selectivity.
@ast
Structure modeling of the chem ...... igand binding and selectivity.
@en
Structure modeling of the chem ...... igand binding and selectivity.
@nl
prefLabel
Structure modeling of the chem ...... igand binding and selectivity.
@ast
Structure modeling of the chem ...... igand binding and selectivity.
@en
Structure modeling of the chem ...... igand binding and selectivity.
@nl
P2860
P1433
P1476
Structure modeling of the chem ...... igand binding and selectivity.
@en
P2093
M Germana Paterlini
P2860
P304
P356
10.1016/S0006-3495(02)75307-1
P407
P577
2002-12-01T00:00:00Z