The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis.
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Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanineMolecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repairAdaptive response of Escherichia coli to alkylation damageIsolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural propertiesIsolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA.Direct assay for O6-methylguanine-DNA methyltransferase and comparison of detection methods for the methylated enzyme in polyacrylamide gels and electroblots.Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanineBCNU for recurrent glioblastoma multiforme: efficacy, toxicity and prognostic factors.Repair of O-alkylpyrimidines in mammalian cells: a present consensus.High frequency of mosaic mutants produced by N-ethyl-N-nitrosourea exposure of mouse zygotes.Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.Repair of O6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosoureaSpontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase.Relationship between schistosomiasis and bladder cancerNeutrophils, nitrogen oxides, and inflammatory bowel disease.Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogoniaExpression of a human O6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice.The nuclear targeting and nuclear retention properties of a human DNA repair protein O6-methylguanine-DNA methyltransferase are both required for its nuclear localization: the possible implicationsRapid, large-scale purification and characterization of 'Ada protein' (O6 methylguanine-DNA methyltransferase) of E. coli.Direct reversal of DNA alkylation damage.Malignant glioma: neuropathology and neurobiology.Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in miceThe in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA.The 1987 Walter Hubert lecture. Regulation and deficiencies in DNA repair.O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.Mutagenesis and transgenic systems: perspective from the mutagen, N-ethyl-N-nitrosourea.After X-irradiation a transient arrest of L929 cells in G2-phase coincides with a rapid elevation of the level of O6-alkylguanine-DNA alkyltransferase.Mechanisms involved in resistance of preirradiated Chinese hamster V79 cells to cytotoxic drugs are multifactoral.Multiple small exposures of filtered mid-UV radiation increase the resistance of Chinese hamster cells to far-UV, mid-UV and filtered mid-UV radiation.Phosphorylation of methylated-DNA-protein-cysteine S-methyltransferase at serine-204 significantly increases its resistance to proteolytic digestion.The detection of alkylation damage in the DNA of human gastrointestinal tissuesMolecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea.The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats.Influence of aging on multi-organ carcinogenesis in rats induced by N-methyl-N-nitrosourea.Expression of human O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells and restoration of cellular resistance to certain N-nitroso compounds.Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines.Contribution of O6-methylguanine-DNA methyltransferase to monofunctional alkylating-agent resistance in human brain tumor-derived cell lines.
P2860
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P2860
The role of O6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis.
description
1985 nî lūn-bûn
@nan
1985 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1985 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1985年の論文
@ja
1985年論文
@yue
1985年論文
@zh-hant
1985年論文
@zh-hk
1985年論文
@zh-mo
1985年論文
@zh-tw
1985年论文
@wuu
name
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@ast
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@en
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@nl
type
label
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@ast
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@en
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@nl
prefLabel
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@ast
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@en
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@nl
P1433
P1476
The role of O6-methylguanine-D ...... utagenesis and carcinogenesis.
@en
P2093
P356
10.1016/0167-8817(85)90034-3
P407
P577
1985-01-01T00:00:00Z