The detection of alkylation damage in the DNA of human gastrointestinal tissues
about
Msh2 status modulates both apoptosis and mutation frequency in the murine small intestineThe nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase.Oxidative DNA damage accumulation in gastric carcinogenesisElevated levels of the pro-carcinogenic adduct, O(6)-methylguanine, in normal DNA from the cancer prone regions of the large bowel.Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents.Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.Meat-related mutagens/carcinogens in the etiology of colorectal cancer.Formation and loss of O6-methyldeoxyguanosine in human leucocyte DNA following sequential DTIC and fotemustine chemotherapy.Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinomaMeat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort StudyHomeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogenGastrointestinal and hepatotoxicity assessment of an anticancer extract from muricid molluscs.The use of an artificial nucleotide for polymerase-based recognition of carcinogenic O6-alkylguanine DNA adducts.Possible mechanisms of alteration in the capacities of carcinogen metabolizing enzymes during schistosomiasis and their role in bladder cancer induction.Protection by Salvia extracts against oxidative and alkylation damage to DNA in human HCT15 and CO115 cells.K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.A highly sensitive and specific method for quantitation of O-alkylated DNA adducts and its application to the analysis of human tissue DNA.The effect of Helicobacter pylori infection on levels of DNA damage in gastric epithelial cells.Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa.Alteration of cytochrome P-450 and glutathione S-transferase activity in normal and malignant human stomach.N-nitrosodimethylamine-derived O(6)-methylguanine in DNA of monkey gastrointestinal and urogenital organs and enhancement by ethanol.O⁶-carboxymethylguanine DNA adduct formation and lipid peroxidation upon in vitro gastrointestinal digestion of haem-rich meat.Detection of methylation damage in DNA of gastric cancer tissues using 32P postlabelling assay.
P2860
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P2860
The detection of alkylation damage in the DNA of human gastrointestinal tissues
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@en
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@nl
type
label
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@en
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@nl
prefLabel
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@en
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@nl
P2093
P2860
P356
P1476
The detection of alkylation damage in the DNA of human gastrointestinal tissues
@en
P2093
P2860
P2888
P356
10.1038/BJC.1991.239
P407
P577
1991-07-01T00:00:00Z