Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.
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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppressionBiology of fibroblasts and myofibroblastsGrowth factors in idiopathic pulmonary fibrosis: relative rolesAltered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosisResolution of Inflammation: What Controls Its Onset?Idiopathic pneumonia syndrome after bone marrow transplantation: the role of pre-transplant radiation conditioning and local cytokine dysregulation in promoting lung inflammation and fibrosisViruses as co-factors for the initiation or exacerbation of lung fibrosisIloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patientsCyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in miceMatrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosisNuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lungHypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGFFuture research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group.Pathogenetic mechanisms in usual interstitial pneumonia/idiopathic pulmonary fibrosis.Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways.Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humansPGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling.Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response factor and myocardin-related transcription factor-AAttenuation of inhibitory prostaglandin E2 signaling in human lung fibroblasts is mediated by phosphodiesterase 4.A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in miceFollowing the path of CCL2 from prostaglandins to periostin in lung fibrosisBasic biology and clinical application of specific cyclooxygenase-2 inhibitors.Immunohistochemical and morphometric evaluation of COX 1 and COX-2 in the remodeled lung in idiopathic pulmonary fibrosis and systemic sclerosisAllergic lung responses are increased in prostaglandin H synthase-deficient mice.Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection.Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.Myofibroblasts: paracrine cells important in health and diseasePathogenesis of idiopathic pulmonary fibrosisDiminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosisThy-1-integrin alphav beta5 interactions inhibit lung fibroblast contraction-induced latent transforming growth factor-beta1 activation and myofibroblast differentiation.Recent advances in the aetiology of cryptogenic fibrosing alveolitis.Lung fibroblasts from patients with idiopathic pulmonary fibrosis exhibit genome-wide differences in DNA methylation compared to fibroblasts from nonfibrotic lungHypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.Histone deacetylase: a potential therapeutic target for fibrotic disordersProstaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics.Lung myofibroblasts are characterized by down-regulated cyclooxygenase-2 and its main metabolite, prostaglandin E2.Novel therapeutic approaches for pulmonary fibrosis.Deficiency of biglycan causes cardiac fibroblasts to differentiate into a myofibroblast phenotype.Cyclooxygenase-2 signaling in vocal fold fibroblastsThy-1 expression regulates the ability of rat lung fibroblasts to activate transforming growth factor-beta in response to fibrogenic stimuli.
P2860
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P2860
Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.
description
1995 nî lūn-bûn
@nan
1995 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@ast
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@en
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@nl
type
label
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@ast
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@en
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@nl
prefLabel
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@ast
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@en
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@nl
P2093
P2860
P356
P1476
Cultured lung fibroblasts isol ...... d to express cyclooxygenase-2.
@en
P2093
L J Crofford
M D Burdick
M Peters-Golden
R M Strieter
S L Kunkel
P2860
P304
P356
10.1172/JCI117866
P407
P577
1995-04-01T00:00:00Z