Transporters in African trypanosomes: role in drug action and resistance.
about
Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.Predictive computational models of substrate binding by a nucleoside transporter.Comparative gene expression of Wigglesworthia inhabiting non-infected and Trypanosoma brucei gambiense-infected Glossina palpalis gambiensis fliesGlossina spp. gut bacterial flora and their putative role in fly-hosted trypanosome developmentTrypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns.Acanthamoeba keratitis update-incidence, molecular epidemiology and new drugs for treatment.Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy.Effective measures for controlling trypanosomiasis.Organic cation transporter 1 (OCT1) is involved in pentamidine transport at the human and mouse blood-brain barrier (BBB).Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.Aquaglyceroporins and metalloid transport: implications in human diseases.Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.Trypanocidal drugs: mechanisms, resistance and new targets.The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.Neglected disease - african sleeping sickness: recent synthetic and modeling advances.Drug discovery and human African trypanosomiasis: a disease less neglected?Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.The animal trypanosomiases and their chemotherapy: a reviewT-2307, a novel arylamidine, is transported into Candida albicans by a high-affinity spermine and spermidine carrier regulated by Agp2.Pyrimidine salvage in Trypanosoma brucei bloodstream forms and the trypanocidal action of halogenated pyrimidines.Design and synthesis of a series of truncated neplanocin fleximers.Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes.Purine nucleobase transport in amastigotes of Leishmania mexicana: involvement in allopurinol uptakeDiphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.Synthesis, inhibition potency, binding mode, and antiprotozoal activities of fluorescent inhibitors of trypanothione reductase based on mepacrine-conjugated diaryl sulfide scaffolds.Different substrate recognition motifs of human and trypanosome nucleobase transporters. Selective uptake of purine antimetabolites.Arginine metabolism in Trypanosoma cruzi is coupled to parasite stage and replication.Parallel synthesis of a series of non-functional ATP/NAD analogs with activity against trypanosomatid parasites.A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats.Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes.Metabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
P2860
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P2860
Transporters in African trypanosomes: role in drug action and resistance.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Transporters in African trypanosomes: role in drug action and resistance.
@ast
Transporters in African trypanosomes: role in drug action and resistance.
@en
Transporters in African trypanosomes: role in drug action and resistance.
@nl
type
label
Transporters in African trypanosomes: role in drug action and resistance.
@ast
Transporters in African trypanosomes: role in drug action and resistance.
@en
Transporters in African trypanosomes: role in drug action and resistance.
@nl
prefLabel
Transporters in African trypanosomes: role in drug action and resistance.
@ast
Transporters in African trypanosomes: role in drug action and resistance.
@en
Transporters in African trypanosomes: role in drug action and resistance.
@nl
P1476
Transporters in African trypanosomes: role in drug action and resistance.
@en
P2093
de Koning HP
P304
P356
10.1016/S0020-7519(01)00167-9
P577
2001-05-01T00:00:00Z