Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
about
The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravisAgrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK)The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formationA pre-metazoan origin of the CRK gene family and co-opted signaling networkCrk and CrkL are required for cell transformation by v-fos and v-ras.Essential roles of Crk and CrkL in fibroblast structure and motility.The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancerCongenital myasthenic syndromes in 2012.Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.Current status of the congenital myasthenic syndromes.Wnt signaling in neuromuscular junction developmentRole of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junctionSorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation.Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis.Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants.MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.Activation of receptor protein-tyrosine kinases from the cytoplasmic compartment.Molecular control of neuromuscular junction developmentStructure of the neuromuscular junction: function and cooperative mechanisms in the synapse.The role of MuSK in synapse formation and neuromuscular disease.Global analysis of muscle-specific kinase signaling by quantitative phosphoproteomics.Musk Kinase Activity is Modulated By A Serine Phosphorylation Site in The Kinase LoopSynaptic Homeostasis and Its Immunological Disturbance in Neuromuscular Junction Disorders.Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.Fibroblast Growth Requires CT10 Regulator of Kinase (Crk) and Crk-like (CrkL).Postnatal knockdown of dok-7 gene expression in mice causes structural defects in neuromuscular synapses and myasthenic pathology.Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners.SRSF1 suppresses selection of intron-distal 5' splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein.Sustained Hox5 gene activity is required for respiratory motor neuron development.Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3γ, and Dok-7 proteins and phosphorylates the latter two.Regulation of muscle acetylcholine receptor turnover by β subunit tyrosine phosphorylation.Overlapping Mechanisms of Peripheral Nerve Regeneration and Angiogenesis Following Sciatic Nerve Transection.Agrin-LRP4-MuSK signaling as a therapeutic target for myasthenia gravis and other neuromuscular disorders.Crk proteins transduce FGF signaling to promote lens fiber cell elongation.Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody.Fundamental Molecules and Mechanisms for Forming and Maintaining Neuromuscular Synapses.Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.
P2860
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P2860
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@ast
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@en
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@nl
type
label
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@ast
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@en
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@nl
prefLabel
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@ast
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@en
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@nl
P2093
P2860
P356
P1433
P1476
Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L
@en
P2093
Chong-Feng Xu
Peter T Hallock
Steven J Burden
Thomas A Neubert
P2860
P304
P356
10.1101/GAD.1977710
P577
2010-11-01T00:00:00Z