Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
about
Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitorPhospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionSynthesis and photophysics of selective functionalized π-conjugated, blue light emitting, highly fluorescent C7-imidazo indolizine derivatives.Secretory phospholipase A2 enzymes as pharmacological targets for treatment of diseaseRandomized trial of an inhibitor of secretory phospholipase A2 on atherogenic lipoprotein subclasses in statin-treated patients with coronary heart disease.(7R,8S,8aS)-8-Hydr-oxy-7-phenyl-perhydro-indolizin-3-oneEosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X.Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells.The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasiaCritical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils.Biochemical characterization of selective inhibitors of human group IIA secreted phospholipase A(2) and hyaluronic acid-linked inhibitor conjugates.5''-(4-Meth-oxy-benzyl-idene)-1'-(4-meth-oxy-phen-yl)-1''-methyl-1',2',3',5',6',7',8',8a'-octa-hydro-dispiro-[acenaphthyl-ene-1,3'-indolizine-2',3''-piperidine]-2,4''(1H)-dione.Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis.Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.Neuroprotective effects of a nanocrystal formulation of sPLA(2) inhibitor PX-18 in cerebral ischemia/reperfusion in gerbilsInvolvement of oxidative pathways in cytokine-induced secretory phospholipase A2-IIA in astrocytes.Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism.Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations.Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Group V Secreted Phospholipase A2 Induces the Release of Proangiogenic and Antiangiogenic Factors by Human Neutrophils.Matrix metalloproteinase-2 negatively regulates cardiac secreted phospholipase A2 to modulate inflammation and fever.(6S,7S,8S,8aS)-6-Ethyl-7,8-dihy-droxy-1,5,6,7,8,8a-hexa-hydro-indolizin-3(2H)-one monohydrate.Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic.Absence of inflammatory conditions in human varicose saphenous veins.Synthesis of substituted indolizines via radical oxidative decarboxylative annulation of 2-(pyridin-2-yl)acetate derivatives with α,β-unsaturated carboxylic acids.Palladium-catalyzed direct and regioselective C-H acyloxylation of indolizines.Discovery of a full-color-tunable fluorescent core framework through direct C-H (hetero)arylation of N-heterocycles.Application of primary halogenated hydrocarbons for the synthesis of 3-aryl and 3-alkyl indolizines.One-pot construction of fused polycyclic heteroarenes involving 7-azaindoles and α,β-unsaturated ketones.
P2860
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P2860
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@ast
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@en
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@nl
type
label
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@ast
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@en
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@nl
prefLabel
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@ast
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@en
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@nl
P2093
P2860
P356
P1476
Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2
@en
P2093
Michael H Gelb
Nathan Cermak
Rob C Oslund
P2860
P304
P356
10.1021/JM800422V
P407
P577
2008-07-08T00:00:00Z