Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
about
Putting a bit into the polo-box domain of polo-like kinase 1Using Ligand-Mapping Simulations to Design a Ligand Selectively Targeting a Cryptic Surface Pocket of Polo-Like Kinase 1Exploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1Design and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.Combinatorial tuning of peptidic drug candidates: high-affinity matriptase inhibitors through incremental structure-guided optimization.The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.Inhibitors of the Polo-Box Domain of Polo-Like Kinase 1.Recent Advances and New Strategies in Targeting Plk1 for Anticancer TherapyNon-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.Development of Bifunctional Inhibitors of Polo-Like Kinase 1 with Low-Nanomolar Activities Against the Polo-Box Domain.Application of oxime-diversification to optimize ligand interactions within a cryptic pocket of the polo-like kinase 1 polo-box domain.Enhancing polo-like kinase 1 selectivity of polo-box domain-binding peptides.Design, synthesis, and evaluation of non-ATP-competitive small-molecule Polo-like kinase 1 (Plk1) inhibitors.Design and Synthesis of Fmoc-Thr[PO(OH)(OPOM)] for the Preparation of Peptide Prodrugs Containing Phosphothreonine in Fully Protected Form
P2860
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P2860
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@ast
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@en
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@nl
type
label
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@ast
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@en
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@nl
prefLabel
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@ast
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@en
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@nl
P2093
P2860
P356
P1433
P1476
Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.
@en
P2093
Andrej Scharow
Jung-Eun Park
Kyung S Lee
Michael B Yaffe
Terrence R Burke
Thorsten Berg
Wen-Jian Qian
P2860
P304
P356
10.1002/CBIC.201200206
P577
2012-05-08T00:00:00Z