Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
about
Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulationUbiquitylation-dependent localization of PLK1 in mitosisIdentification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathwayPLK-1 Targeted Inhibitors and Their Potential against TumorigenesisPutting a bit into the polo-box domain of polo-like kinase 1Molecular dynamics of PLK1 during mitosisFrom Crystal Packing to Molecular Recognition: Prediction and Discovery of a Binding Site on the Surface of Polo-Like Kinase 1Serendipitous alkylation of a Plk1 ligand uncovers a new binding channelStructural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human SurvivinIdentification of High Affinity Polo-like Kinase 1 (Plk1) Polo-box Domain Binding Peptides Using Oxime-Based DiversificationExploring the Binding Nature of Pyrrolidine Pocket-Dependent Interactions in the Polo-Box Domain of Polo-Like Kinase 1High-Throughput Interrogation of Ligand Binding Mode Using a Fluorescence-Based AssayAlteration of fluorescent protein spectroscopic properties upon cryoprotectionMolecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesisStructural basis for the inhibition of Polo-like kinase 1Structural analysis of the polo-box domain of human Polo-like kinase 2Novel peptide-mediated interactions derived from high-resolution 3-dimensional structuresDynamic and multi-pharmacophore modeling for designing polo-box domain inhibitorsDesign and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assayNeighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocyclesTargeting kinase signaling pathways with constrained peptide scaffolds.High mitotic activity of Polo-like kinase 1 is required for chromosome segregation and genomic integrity in human epithelial cells.Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization.Mechanisms underlying Plk1 polo-box domain-mediated biological processes and their physiological significance.Preparation of orthogonally protected (2S, 3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) as a phosphatase-stable phosphothreonine mimetic and its use in the synthesis of Polo-box domain-binding peptides.Current progress and future perspectives in the development of anti-polo-like kinase 1 therapeutic agents.Polo-box domain: a versatile mediator of polo-like kinase function.Exploring Potential Binding Modes of Small Drug-like Molecules to the Polo-Box Domain of Human Polo-like Kinase 1.Plk1-targeted small molecule inhibitors: molecular basis for their potency and specificity.Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1.The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores.Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochoresPolo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.Investigation of unanticipated alkylation at the N(π) position of a histidyl residue under Mitsunobu conditions and synthesis of orthogonally protected histidine analogues.Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer TreatmentInhibitors of the Polo-Box Domain of Polo-Like Kinase 1.Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation.STIL binding to Polo-box 3 of PLK4 regulates centriole duplicationProteomic identification of novel cytoskeletal proteins associated with TbPLK, an essential regulator of cell morphogenesis in Trypanosoma brucei
P2860
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P2860
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural and functional anal ...... x domain of polo-like kinase 1
@ast
Structural and functional anal ...... x domain of polo-like kinase 1
@en
Structural and functional anal ...... x domain of polo-like kinase 1
@nl
type
label
Structural and functional anal ...... x domain of polo-like kinase 1
@ast
Structural and functional anal ...... x domain of polo-like kinase 1
@en
Structural and functional anal ...... x domain of polo-like kinase 1
@nl
prefLabel
Structural and functional anal ...... x domain of polo-like kinase 1
@ast
Structural and functional anal ...... x domain of polo-like kinase 1
@en
Structural and functional anal ...... x domain of polo-like kinase 1
@nl
P2093
P2860
P50
P356
P1476
Structural and functional anal ...... x domain of polo-like kinase 1
@en
P2093
Akira Otaka
Chenzhong Liao
Do-Young Yoon
Dong-Hee Lee
James B McMahon
Jeong K Bang
Jung-Eun Park
Kyung S Lee
P2860
P2888
P304
P356
10.1038/NSMB.1628
P577
2009-08-01T00:00:00Z
P6179
1041922521