Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.
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Role of EPAC in cAMP-Mediated Actions in Adrenocortical CellsMultiple treatments with L-3,4-dihydroxyphenylalanine modulate dopamine biosynthesis and neurotoxicity through the protein kinase A-transient extracellular signal-regulated kinase and exchange protein activation by cyclic AMP-sustained extracellularGβγ subunits inhibit Epac-induced melanoma cell migration.Differential roles of Epac in regulating cell death in neuronal and myocardial cells.PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis.Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messengerInhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells.Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.Phosphodiesterase 4 inhibitors augment levels of glucocorticoid receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cellscAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytesChronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors.EPAC proteins transduce diverse cellular actions of cAMP.Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells.Multiple cAMP-induced signaling cascades regulate prolactin expression in T cells.The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function.Targeting cancer with phosphodiesterase inhibitors.New methods for the discovery and synthesis of PDE7 inhibitors as new drugs for neurological and inflammatory disorders.Targeting cAMP in chronic lymphocytic leukemia: a pathway-dependent approach for the treatment of leukemia and lymphoma.cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).Epac1 knockdown inhibits the proliferation of ovarian cancer cells by inactivating AKT/Cyclin D1/CDK4 pathway in vitro and in vivo.Elevation of cAMP Levels Inhibits Doxorubicin-Induced Apoptosis in Pre- B ALL NALM- 6 Cells Through Induction of BAD Phosphorylation and Inhibition of P53 Accumulation.Epac1 increases migration of endothelial cells and melanoma cells via FGF2-mediated paracrine signaling.Exchange protein directly activated by cAMP 1 (Epac1) is expressed in human neutrophils and mediates cAMP-dependent activation of the monomeric GTPase Rap1.Cyclic AMP-induced p53 destabilization is independent of EPAC in pre-B acute lymphoblastic leukemia cells in vitro.Epac1 promotes melanoma metastasis via modification of heparan sulfate.Elevation of cyclic AMP causes an imbalance between NF-kappaB and p53 in NALM-6 cells treated by doxorubicin.Activation of cAMP signaling interferes with stress-induced p53 accumulation in ALL-derived cells by promoting the interaction between p53 and HDM2PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner.The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1.Phosphorylation of the guanine-nucleotide-exchange factor CalDAG-GEFI by protein kinase A regulates Ca(2+)-dependent activation of platelet Rap1b GTPase.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Calcium-RasGRP2-Rap1 signaling mediates CD38-induced migration of chronic lymphocytic leukemia cells
P2860
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P2860
Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis.
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@ast
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@en
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@nl
type
label
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@ast
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@en
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@nl
prefLabel
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@ast
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@en
Among circulating hematopoieti ...... 4 inhibitor-induced apoptosis.
@nl
P50
P1433
P1476
Among circulating hematopoieti ...... E4 inhibitor-induced apoptosis
@en
P2093
Amanda Flies
Eun-Yi Moon
P304
P356
10.1182/BLOOD-2003-06-2154
P407
P577
2003-11-13T00:00:00Z