Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo. - Wikidata - awgldk - TriplyDB

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

http://www.wikidata.org/entity/Q34276697

about

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts Promising Therapy Candidates for Liver Fibrosis Role of redoximiRs in fibrogenesis Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis Role of NADPH oxidases in the redox biology of liver fibrosis Therapeutic targeting of redox signaling in myofibroblast differentiation and age-related fibrotic disease The hepatic cannabinoid 1 receptor as a modulator of hepatic energy state and food intake Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement Myofibroblasts Oxidative stress and pulmonary fibrosis Physiological and pathological functions of NADPH oxidases during myocardial ischemia-reperfusion Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014.Nuclear Factor-Erythroid-2-Related Factor 2 in Aging and Lung Fibrosis Liver fibrosis and protection mechanisms action of medicinal plants targeting apoptosis of hepatocytes and hepatic stellate cells Characterization of pressure-mediated vascular tone in resistance arteries from bile duct-ligated rats.Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling.Role of NADPH oxidases in liver fibrosis.The quest for selective nox inhibitors and therapeutics: challenges, triumphs and pitfalls NADPH oxidase, NOX1, mediates vascular injury in ischemic retinopathy.Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation Diabetes alters activation and repression of pro- and anti-inflammatory signaling pathways in the vasculature.Updates of reactive oxygen species in melanoma etiology and progression.NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina.The Nox1/4 Dual Inhibitor GKT137831 or Nox4 Knockdown Inhibits Angiotensin-II-Induced Adult Mouse Cardiac Fibroblast Proliferation and Migration. AT1 Physically Associates With Nox4.Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease.Fuzheng Huayu recipe alleviates hepatic fibrosis via inhibiting TNF-α induced hepatocyte apoptosis.Upstream regulators and downstream effectors of NADPH oxidases as novel therapeutic targets for diabetic kidney disease.Hydrogen Sulfide: A Therapeutic Candidate for Fibrotic Disease?Targeting NADPH oxidase with a novel dual Nox1/Nox4 inhibitor attenuates renal pathology in type 1 diabetes.Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation.Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.Dermal delivery of HSP47 siRNA with NOX4-modulating mesoporous silica-based nanoparticles for treating fibrosis.

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Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831, a novel NOX4/NOX1 inhibitor in vivo.

http://www.wikidata.org/entity/Q34276697

description

2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012 թվականի մայիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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type

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Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

@ast

Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

@en

Liver fibrosis and hepatocyte ...... l NOX4/NOX1 inhibitor in vivo.

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J.FREERADBIOMED.2012.05.007

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Free Radical Biology and Medicine

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Liver fibrosis and hepatocyte ...... el NOX4/NOX1 inhibitor in vivo

@en

P2093

Cédric Szyndralewiez

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Joy X Jiang

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Natalie J Török

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Nobuko Serizawa

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Patrick Page

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Sridevi Devaraj

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Xiangling Chen

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P2860

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

Mechanisms of hepatic fibrogenesis

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase.

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice

Hepatocyte NAD(P)H oxidases as an endogenous source of reactive oxygen species during hepatitis C virus infection.

Oxidative and nitrosative stress and fibrogenic response.

Mechanisms of disease progression in nonalcoholic fatty liver disease.

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289-296

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scholarly article

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10.1016/J.FREERADBIOMED.2012.05.007

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2

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53

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Katrin Schröder

Ralf P. Brandes

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2012-05-19T00:00:00Z

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22618020

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3392471

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