Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain - Wikidata - awgldk - TriplyDB

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

http://www.wikidata.org/entity/Q27652468

about

RTX proteins: a highly diverse family secreted by a common mechanism The acetyltransferase activity of the bacterial toxin YopJ of Yersinia is activated by eukaryotic host cell inositol hexakisphosphate Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins Cross Kingdom Activators of Five Classes of Bacterial Effectors Clostridial toxins: sensing a target in a hostile gut environment.Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A Structural and Molecular Mechanism for Autoprocessing of MARTX Toxin of Vibrio cholerae at Multiple Sites Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin Rational Design of Inhibitors and Activity-Based Probes Targeting Clostridium difficile Virulence Factor TcdB Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins Structure of the catalytic domain of theSalmonellavirulence factor SseI Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation Crystal structure of a Trypanosoma brucei metacaspase Structure of a pathogen effector reveals the enzymatic mechanism of a novel acetyltransferase family Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.Using small molecules to dissect mechanisms of microbial pathogenesis.Small-molecule activators of a proenzyme.Allosteric regulation of protease activity by small molecules.Inositol hexakisphosphate-induced autoprocessing of large bacterial protein toxins.BINANA: a novel algorithm for ligand-binding characterization Expression of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) and its role in neural tube defects.Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.Emerging principles in protease-based drug discovery.Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics Human caspases: activation, specificity, and regulation Small-molecule procaspase activators identified using fluorescence polarization.Autoproteolytic activation of bacterial toxins.Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome.Toward a structural understanding of Clostridium difficile toxins A and B.Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.New approaches for dissecting protease functions to improve probe development and drug discovery Rhomboid protease dynamics and lipid interactions The origin of allosteric functional modulation: multiple pre-existing pathways.Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.Regulation of Vibrio parahaemolyticus T3SS2 gene expression and function of T3SS2 effectors that modulate actin cytoskeleton.Comparative structural analysis of the caspase family with other clan CD cysteine peptidases.Two serine residues in Pseudomonas syringae effector HopZ1a are required for acetyltransferase activity and association with the host co-factor.

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P2860

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

http://www.wikidata.org/entity/Q27652468

description

2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Small Molecule-Induced Alloste ...... e RTX Cysteine Protease Domain

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Aimee Shen

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K Christopher Garcia

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Patrick J Lupardus

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P2860

Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold

Back in the water: the return of the inositol phosphates

Autoprocessing of the Vibrio cholerae RTX toxin by the cysteine protease domain

Structure-function analysis of inositol hexakisphosphate-induced autoprocessing of the Vibrio cholerae multifunctional autoprocessing RTX toxin

Prolonged colonization of mice by Vibrio cholerae El Tor O1 depends on accessory toxins

Hemolysin and the multifunctional autoprocessing RTX toxin are virulence factors during intestinal infection of mice with Vibrio cholerae El Tor O1 strains

Discovery of an allosteric site in the caspases

Inositol derivatives: evolution and functions.

Proteolytic activation of bacterial toxins: role of bacterial and host cell proteases.

RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae

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scholarly article

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10.1126/SCIENCE.1162403

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5899

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322

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23310065

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18845756

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Vibrio cholerae

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3272704

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