Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody. - Wikidata - awgldk - TriplyDB

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody.

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody.

http://www.wikidata.org/entity/Q34283442

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Ig Constant Region Effects on Variable Region Structure and Function Global structures of IgG isotypes expressing identical variable regions Structure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulation The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition The Structural Basis of Antibody-Antigen Recognition Broadly neutralizing anti-influenza virus antibodies: enhancement of neutralizing potency in polyclonal mixtures and IgA backbones.IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly γ-D-glutamic acid capsular antigen of Bacillus anthracis.Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission The road to toxin-targeted therapeutic antibodies.HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.Thermodynamic analysis of the binding of 2F5 (Fab and immunoglobulin G forms) to its gp41 epitope reveals a strong influence of the immunoglobulin Fc region on affinity.Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes.A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patients Synergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones.Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.Variable Region Identical IgA and IgE to Cryptococcus neoformans Capsular Polysaccharide Manifest Specificity Differences.Purification and functional characterization of mucosal IgA from vaccinated and SIV-infected rhesus macaques Anti-DNA antibody mediated catalysis is isotype dependent.Immunoglobulin isotype influences affinity and specificity.Plasmid DNA Vaccine Co-Immunisation Modulates Cellular and Humoral Immune Responses Induced by Intranasal Inoculation in Mice.Variable region identical immunoglobulins differing in isotype express different paratopes.Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance.Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.Neutralizing IgG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challenge Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection.Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies.Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations.Human immunodeficiency virus antibodies and the vaccine problem.Comparative analysis of plant-produced, recombinant dimeric IgA against cell wall β-glucan of pathogenic fungi.Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent Manner Scarcity of autoreactive human blood IgA+ memory B cells.A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles.Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity.VH and VL Domains of Polyspecific IgM and Monospecific IgG Antibodies Contribute Differentially to Antigen Recognition and Virus Neutralization Functions.Clinical severity of visceral leishmaniasis is associated with changes in immunoglobulin g fc N-glycosylation.Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs.Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.Comparison of antiviral activity between IgA and IgG specific to influenza virus hemagglutinin: increased potential of IgA for heterosubtypic immunity.

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P2860

Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody.

http://www.wikidata.org/entity/Q34283442

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

@ast

Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

@en

Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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type

label

Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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prefLabel

Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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Proceedings of the National Academy of Sciences of the United States of America

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Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.

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P2093

Anne-Sophie Drillet

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Daniela Tudor

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Huifeng Yu

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Pierre Tuffery

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Tahar Bouceba

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P2860

Few and far between: how HIV may be evading antibody avidity

Crystal structure of HIV-1 gp41 including both fusion peptide and membrane proximal external regions

T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension

Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure

A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies

HIV entry and its inhibition

Fine definition of the epitope on the gp41 glycoprotein of human immunodeficiency virus type 1 for the neutralizing monoclonal antibody 2F5.

Epitope mapping using combinatorial phage-display libraries: a graph-based algorithm.

Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope algorithm.

Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing

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12680-12685

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109

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Isabelle Schwartz-Cornil

Julien Maupetit

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235615667

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