Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody.
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Ig Constant Region Effects on Variable Region Structure and FunctionGlobal structures of IgG isotypes expressing identical variable regionsStructure of a human IgA1 Fab fragment at 1.55 Å resolution: potential effect of the constant domains on antigen-affinity modulationThe Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cellsOvercoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral InhibitionThe Structural Basis of Antibody-Antigen RecognitionBroadly neutralizing anti-influenza virus antibodies: enhancement of neutralizing potency in polyclonal mixtures and IgA backbones.IgG subclass and heavy chain domains contribute to binding and protection by mAbs to the poly γ-D-glutamic acid capsular antigen of Bacillus anthracis.Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmissionThe road to toxin-targeted therapeutic antibodies.HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.Thermodynamic analysis of the binding of 2F5 (Fab and immunoglobulin G forms) to its gp41 epitope reveals a strong influence of the immunoglobulin Fc region on affinity.Randomized Phase I: Safety, Immunogenicity and Mucosal Antiviral Activity in Young Healthy Women Vaccinated with HIV-1 Gp41 P1 Peptide on Virosomes.A nonparametric procedure for defining a new humoral immunologic profile in a pilot study on HIV infected patientsSynergy in monoclonal antibody neutralization of HIV-1 pseudoviruses and infectious molecular clones.Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge.Variable Region Identical IgA and IgE to Cryptococcus neoformans Capsular Polysaccharide Manifest Specificity Differences.Purification and functional characterization of mucosal IgA from vaccinated and SIV-infected rhesus macaquesAnti-DNA antibody mediated catalysis is isotype dependent.Immunoglobulin isotype influences affinity and specificity.Plasmid DNA Vaccine Co-Immunisation Modulates Cellular and Humoral Immune Responses Induced by Intranasal Inoculation in Mice.Variable region identical immunoglobulins differing in isotype express different paratopes.Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance.Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG.Neutralizing IgG at the portal of infection mediates protection against vaginal simian/human immunodeficiency virus challengeNeutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection.Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies.Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells.Induction of HIV-blocking anti-CCR5 IgA in Peyers's patches without histopathological alterations.Human immunodeficiency virus antibodies and the vaccine problem.Comparative analysis of plant-produced, recombinant dimeric IgA against cell wall β-glucan of pathogenic fungi.Monoclonal Antibodies Specific for the V2, V3, CD4-Binding Site, and gp41 of HIV-1 Mediate Phagocytosis in a Dose-Dependent MannerScarcity of autoreactive human blood IgA+ memory B cells.A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles.Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity.VH and VL Domains of Polyspecific IgM and Monospecific IgG Antibodies Contribute Differentially to Antigen Recognition and Virus Neutralization Functions.Clinical severity of visceral leishmaniasis is associated with changes in immunoglobulin g fc N-glycosylation.Recombinant IgA is sufficient to prevent influenza virus transmission in guinea pigs.Aggregates, crystals, gels, and amyloids: intracellular and extracellular phenotypes at the crossroads of immunoglobulin physicochemical property and cell physiology.Comparison of antiviral activity between IgA and IgG specific to influenza virus hemagglutinin: increased potential of IgA for heterosubtypic immunity.
P2860
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P2860
Isotype modulates epitope specificity, affinity, and antiviral activities of anti-HIV-1 human broadly neutralizing 2F5 antibody.
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@ast
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@en
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@nl
type
label
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@ast
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@en
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@nl
prefLabel
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@ast
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@en
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@nl
P2093
P2860
P50
P356
P1476
Isotype modulates epitope spec ...... dly neutralizing 2F5 antibody.
@en
P2093
Anne-Sophie Drillet
Daniela Tudor
Huifeng Yu
Pierre Tuffery
Tahar Bouceba
P2860
P304
12680-12685
P356
10.1073/PNAS.1200024109
P407
P577
2012-06-20T00:00:00Z