Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL - Wikidata - awgldk - TriplyDB

Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL

Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL

http://www.wikidata.org/entity/Q34285051

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Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy Molecular targets of TRAIL-sensitizing agents in colorectal cancer Marine Drugs Regulating Apoptosis Induced by Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)Targeting Mcl-1 for the therapy of cancer Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells Oxidative stress induces monocyte necrosis with enrichment of cell-bound albumin and overexpression of endoplasmic reticulum and mitochondrial chaperones Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis.Phosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.Proteomic analysis of gossypol induces necrosis in multiple myeloma cells.Death receptor 5 expression is inversely correlated with prostate cancer progression.ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins.Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway.Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy Adenovirus-mediated co-expression of the TRAIL and HN genes inhibits growth and induces apoptosis in Marek's disease tumor cell line MSB-1.(-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis.Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.Lactobacillus casei Exerts Anti-Proliferative Effects Accompanied by Apoptotic Cell Death and Up-Regulation of TRAIL in Colon Carcinoma Cells.Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells.Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells.Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis Prevention and Treatment of Colorectal Cancer by Natural Agents From Mother Nature.Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy Differential effect of grape seed extract against human non-small-cell lung cancer cells: the role of reactive oxygen species and apoptosis induction.Sub-toxic dose of apigenin sensitizes HepG2 cells to TRAIL through ERK-dependent up-regulation of TRAIL receptor DR5.Inhibition of PRC2 histone methyltransferase activity increases TRAIL-mediated apoptosis sensitivity in human colon cancer cells TRAIL combinations: The new 'trail' for cancer therapy (Review).Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis.Combinatorial treatment with anacardic acid followed by TRAIL augments induction of apoptosis in TRAIL resistant cancer cells by the regulation of p53, MAPK and NFκβ pathways.Inhibition of JNK3 promotes apoptosis induced by BH3 mimetic S1 in chemoresistant human ovarian cancer cells.The chalcone 2'-hydroxy-4',5'-dimethoxychalcone activates death receptor 5 pathway and leads to apoptosis in human nonsmall cell lung cancer cells.Gossypol induces apoptosis in ovarian cancer cells through oxidative stress.Natural Bcl-2 inhibitor (-)- gossypol induces protective autophagy via reactive oxygen species-high mobility group box 1 pathway in Burkitt lymphoma.Snake venom toxin from Vipera lebetina turanica sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins.AW00179 potentiates TRAIL-mediated death of human lung cancer H1299 cells through ROS-JNK-c-Jun-mediated up-regulation of DR5 and down-regulation of anti-apoptotic molecules.

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P2860

Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL

http://www.wikidata.org/entity/Q34285051

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@ast

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@en

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@nl

type

label

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@ast

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@en

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@nl

prefLabel

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@ast

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@en

Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@nl

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JBC.M110.172767

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Journal of Biological Chemistry

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Gossypol induces death recepto ...... es colon cancer cells to TRAIL

@en

P2093

Bharat B Aggarwal

http://www.w3.org/2001/XMLSchema#string

Bokyung Sung

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Jayaraj Ravindran

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Manoj K Pandey

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Sahdeo Prasad

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P2860

CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family

The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain

Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.

From receptors to stress-activated MAP kinases

TRAIL receptor-2 signals apoptosis through FADD and caspase-8

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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35418-35427

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scholarly article

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10.1074/JBC.M110.172767

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46

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285

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2010-09-13T00:00:00Z

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20837473

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2975165

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