Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease. - Wikidata - awgldk - TriplyDB

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

http://www.wikidata.org/entity/Q34293057

about

Tau Proteins and Neurofibrillary Degeneration Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease Tau-tubulin kinase Utilizing the peptidyl-prolyl cis-trans isomerase pin1 as a probe of its phosphorylated target proteins. Examples of binding to nuclear proteins in a human kidney cell line and to tau in Alzheimer's diseased brain.Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease.Human cyclophilin 40 unravels neurotoxic amyloids.Mechanisms of tau-induced neurodegeneration.Dynamic changes of the phosphoproteome in postmortem mouse brains.Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration Biomarkers of Alzheimer's disease risk in peripheral tissues; focus on buccal cells.Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.Tau in Alzheimer disease and related tauopathies.Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.Developing pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level.Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.Detection of a Cdc2-related kinase associated with Alzheimer paired helical filaments.Heterogeneity of tau proteins in Alzheimer's disease. Evidence for increased expression of an isoform and preferential distribution of a phosphorylated isoform in neurites.Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies.Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice Twisted ribbon structure of paired helical filaments revealed by atomic force microscopy.A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly Cornel Iridoid Glycoside Attenuates Tau Hyperphosphorylation by Inhibition of PP2A Demethylation Biological function of Presenilin and its role in AD pathogenesis Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease.Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.17beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner.Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.Protein phosphorylation: changes with age and age-related diseases.Hyperphosphorylated tau in SY5Y cells: similarities and dissimilarities to abnormally hyperphosphorylated tau from Alzheimer disease brain.Molecular mechanism of Alzheimer's neurofibrillary degeneration and therapeutic intervention.Age-dependent changes in the ultrastructure and in the molecular composition of rat brain microtubules.Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site.Aging and neurogenesis, a lesion from Alzheimer's disease.

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P2860

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.

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1989 nî lūn-bûn

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1989年の論文

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Identification and localizatio ...... ilaments of Alzheimer disease.

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Identification and localizatio ...... ilaments of Alzheimer disease.

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A J Smith

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P2860

A protein factor essential for microtubule assembly

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

The distribution of tau in the mammalian central nervous system

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin.

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly.

Microtubule assembly in the absence of added nucleotides.

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Alzheimer's disease

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