Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.
about
Melatonin in Alzheimer's disease and other neurodegenerative disordersmTOR-dependent signalling in Alzheimer's diseasePropofol directly increases tau phosphorylationI1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2ANeuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational controlMammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer diseaseThe excitotoxin quinolinic acid induces tau phosphorylation in human neuronsThe extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review).Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi.Dysregulation of tau phosphorylation in mouse brain during excitotoxic damageMechanisms of tau-induced neurodegeneration.Microcystin congener- and concentration-dependent induction of murine neuron apoptosis and neurite degeneration.Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic targetUp-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.Developing pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degenerationThe carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice.Glutamate system, amyloid ß peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathologyA decade of tau transgenic animal models and beyond.Use of okadaic acid to identify relevant phosphoepitopes in pathology: a focus on neurodegenerationTau-based treatment strategies in neurodegenerative diseasesAcetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanismOriginal Research: Influence of okadaic acid on hyperphosphorylation of tau and nicotinic acetylcholine receptors in primary neuronsPharmacotherapeutic targets in Alzheimer's diseasePhosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathologyMechanism of okadaic acid-induced neuronal death and the effect of estrogensTau as a therapeutic target for Alzheimer's diseaseMolecular and cellular mechanism of okadaic acid (OKA)-induced neurotoxicity: a novel tool for Alzheimer's disease therapeutic application.Activation of mTOR: a culprit of Alzheimer's disease?Does any drug to treat cancer target mTOR and iron hemostasis in neurodegenerative disorders?Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction.The involvement of glycogen synthase kinase-3 and protein phosphatase-2A in lactacystin-induced tau accumulation.P70 S6 kinase mediates tau phosphorylation and synthesis.Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells.High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction.The role of CDK5 and GSK3B kinases in hyperphosphorylation of microtubule associated protein tau (MAPT) in Alzheimer's disease.Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion
P2860
Q28217483-94A3E6A9-2C51-48C0-BB98-3084D5A6D0AFQ28308319-4CD73585-6CBF-42AE-B7C9-84A0FA58488BQ28477036-723C5EA5-EE81-4340-A4DB-B014AD69D0D1Q28566668-3188E568-BE03-4F71-A743-2F6752DDB32FQ28570179-C1C1AF81-2A55-4781-B5AC-0C61E2B6A243Q30412891-555580DE-4AF8-4B04-A04D-C0CC0C68ED70Q33485236-C43D2A38-5B0B-4425-8235-B4E11FF41EF2Q33674924-228E2755-0E99-41E9-A96F-A270C70169D6Q33689110-F588E5AD-6363-4C36-AF30-5EAC01F9253AQ33691114-D31831FF-5824-4B08-BE9E-53AF652E15A9Q33859830-7C4E4AD5-231B-402E-B2B7-264E6462D1E5Q34024867-ABA39BC8-7BE7-47A8-9CDE-19CB5BE4761AQ34283467-656AFBFC-3996-44FF-8417-EE0D7D491ACAQ35016882-3359118D-7C58-4ED8-9F43-90F5A231BAE9Q35083891-2FDB4002-AB3C-449B-8682-F50E485116C0Q35114786-817C19B9-EFC1-42E4-BCA7-355696505F0AQ35114797-4715AF3C-F512-49CA-B6A6-9896D7150AEAQ35327851-50CE8168-4167-4EA6-97E0-C5548673B5AEQ35588860-C9852D8C-04E7-464E-8FCA-B1B9A3B657E4Q35791948-8DD89540-24B1-467E-97A9-1FCFF66F34A4Q36485712-7C4E1AB4-475A-43FD-864D-8AFB4CC1C042Q36817223-F6AE31AA-3F0F-459D-90B0-B3C9635E3FAFQ36999161-74492C06-5F15-4237-A443-7F88542D85C1Q37215861-B6E0E11B-F271-477D-A727-70DF13FE50ABQ37252086-69A6ADDF-E102-441F-9721-FD4F78E8E32CQ37265433-30A083E5-C7DC-43D3-95F7-2EE3DB3B07A5Q37295067-6727968E-0AF9-40AA-BFAE-5AB50DA9B8DBQ37296372-E29F9B5E-1117-446E-837D-2F4B04EB25CDQ37307470-1164EF96-85AD-42DF-997A-B4492291B5C0Q37890451-D23213B8-D03B-41F4-A03D-2D4DEB0F46E9Q38202889-BC7B935D-D3BE-41A6-BFDE-493C1F4EB352Q38443497-3B745866-2AAC-49CB-BFF3-4F08DD143E20Q39010650-F80B4867-F66C-4DD4-9019-6FE1ADCADCCAQ40037612-9ECAFDBE-6EE7-48BB-A894-2616FA84F984Q40287761-4010A793-3925-4DEC-B01F-3EDB6A312407Q40338655-F7F7EC7F-48A4-45C4-AEE4-631D9C9C164EQ40457386-4FAEA9A0-B7CF-45BA-947A-4D6AD7D5BEFAQ41093396-D8E1BC9F-7761-4F55-8FA7-CAD4019E5E33Q41906743-07CC885E-DE46-4E82-8A03-FC8323892D18Q42836513-8BE18494-3A84-4167-982F-AEEA92F27F7E
P2860
Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@ast
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@en
type
label
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@ast
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@en
prefLabel
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@ast
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@en
P2093
P2860
P1476
Okadaic-acid-induced inhibitio ...... o that in Alzheimer's disease.
@en
P2093
Cheng-Xin Gong
Jin-Jing Pei
Khalid Iqbal
Richard F Cowburn
Wen-Lin An
P2860
P304
P356
10.1016/S0002-9440(10)63445-1
P407
P577
2003-09-01T00:00:00Z