Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
about
Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivationTargeting Th17 Cells with Small Molecules and Small Interference RNABenzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH 17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγIdentification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell DifferentiationTransient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cellsRetinoic acid actions through mammalian nuclear receptors.RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxyvitamin D.T cell activation and differentiation is modulated by a CD6 domain 1 antibody ItolizumabRetinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes.CD4 aptamer-RORγt shRNA chimera inhibits IL-17 synthesis by human CD4(+) T cells.Small-molecule control of cytokine function: new opportunities for treating immune disordersCelastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.PLZF regulates CCR6 and is critical for the acquisition and maintenance of the Th17 phenotype in human cells.Phosphoenolpyruvate Carboxykinase, a Key Enzyme That Controls Blood Glucose, Is a Target of Retinoic Acid Receptor-Related Orphan Receptor αThe Role of IL-17 and Th17 Lymphocytes in Autoimmune DiseasesClinical use of biologics in vasculitis syndromes.Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivityRetinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism.Digoxin reduces atherosclerosis in apolipoprotein E-deficient miceCD4(+) T-cell subsets in intestinal inflammationIdentification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists.Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.Emerging new roles of Th17 cells.Inhibition of IL-17 as a pharmacological approach for IBD.Emerging immunotherapies for rheumatoid arthritis.Signaling Pathways and Epigenetic Regulations in the Control of RORγt Expression in T Helper 17 Cells.Th17 response and its regulation in inflammatory upper airway diseases.Th17 cells in autoimmune diseases.Metabolism of murine TH 17 cells: Impact on cell fate and functionA mechanistic review of silica-induced inhalation toxicity.T-bet as a key regulator of mucosal immunity.Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease.Nuclear receptor function in skin health and disease: therapeutic opportunities in the orphan and adopted receptor classes.Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.RORγt, a multitask nuclear receptor at mucosal surfaces.Interluekin-17A (IL17A).Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists.Follistatin-like protein 1 modulates IL-17 signaling via IL-17RC regulation in stromal cells.
P2860
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P2860
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@ast
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@en
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@nl
type
label
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@ast
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@en
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@nl
prefLabel
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@ast
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@en
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@nl
P2860
P356
P1476
Small molecule inhibitors of RORγt: targeting Th17 cells and other applications.
@en
P2093
Dan R Littman
P2860
P304
P356
10.1002/EJI.201242740
P407
P577
2012-09-01T00:00:00Z