General anesthetics predicted to block the GLIC pore with micromolar affinity.
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The molecular pharmacology of volatile anestheticsExploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computationCommon Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion ChannelMultisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)Structural basis for ion permeation mechanism in pentameric ligand-gated ion channelsMolecular mechanism for the dual alcohol modulation of Cys-loop receptorsIn silico analysis reveals sequential interactions and protein conformational changes during the binding of chemokine CXCL-8 to its receptor CXCR1A Structural Model of the Human α7 Nicotinic Receptor in an Open ConformationPropofol binding to the resting state of the gloeobacter violaceus ligand-gated ion channel (GLIC) induces structural changes in the inter- and intrasubunit transmembrane domain (TMD) cavitiesA membrane-embedded pathway delivers general anesthetics to two interacting binding sites in the Gloeobacter violaceus ion channel.Atomistic models of general anesthetics for use in in silico biological studiesStructural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion ChannelDirect Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels.Stabilization of the GluCl ligand-gated ion channel in the presence and absence of ivermectinInhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sitesFunctional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channelsA Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.Barbiturates Bind in the GLIC Ion Channel Pore and Cause Inhibition by Stabilizing a Closed State.Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.Pentameric Ligand-gated Ion Channels : Insights from Computation.Concentration-Dependent Binding of Small Ligands to Multiple Saturable Sites in Membrane Proteins.The cellular membrane as a mediator for small molecule interaction with membrane proteins.String method solution of the gating pathways for a pentameric ligand-gated ion channel.Ketamine Inhibition of the Pentameric Ligand-Gated Ion Channel GLIC.Simulation of Ligand Binding to Membrane Proteins.n-Dodecyl β-D-maltoside specifically competes with general anesthetics for anesthetic binding sites.Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
P2860
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P2860
General anesthetics predicted to block the GLIC pore with micromolar affinity.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@ast
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@en
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@nl
type
label
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@ast
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@en
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@nl
prefLabel
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@ast
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@en
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@nl
P2860
P50
P1476
General anesthetics predicted to block the GLIC pore with micromolar affinity.
@en
P2093
David N LeBard
Michael L Klein
P2860
P304
P356
10.1371/JOURNAL.PCBI.1002532
P577
2012-05-31T00:00:00Z