Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us?
about
ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomesMutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity.Designing siRNA that distinguish between genes that differ by a single nucleotidePromises and challenges in developing RNAi as a research tool and therapy for neurodegenerative diseases.Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progressionWidespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.Endogenous protectant kynurenic acid in amyotrophic lateral sclerosis.A chemical chaperone-based drug candidate is effective in a mouse model of amyotrophic lateral sclerosis (ALS).
P2860
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P2860
Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us?
description
2000 nî lūn-bûn
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2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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Mechanism and treatment of mot ...... hat have SOD1 mutants told us?
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10.1080/14660820050515052
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2000-09-01T00:00:00Z