Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression - Wikidata - awgldk - TriplyDB

Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression

Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression

http://www.wikidata.org/entity/Q36701874

about

Non-Viral Nucleic Acid Delivery Strategies to the Central Nervous System Progress toward in vivo use of siRNAs-II Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model.Rationale for therapeutic silencing of alpha-synuclein in Parkinson's disease Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS.A high-throughput screen to identify inhibitors of SOD1 transcription.Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models Allele-specific silencing of mutant Ataxin-7 in SCA7 patient-derived fibroblasts.Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1.Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats.Gene regulation by non-coding RNAs.Structural Dynamics of Human Argonaute2 and Its Interaction with siRNAs Designed to Target Mutant tdp43.Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis.New therapeutic targets for amyotrophic lateral sclerosis.Research advances in gene therapy approaches for the treatment of amyotrophic lateral sclerosis.Small RNA drugs for prion disease: a new frontier.Oxidative stress, a common molecular pathway for kidney disease: role of the redox enzyme p66Shc.Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson's Disease.Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis.

P2860

Q28068242-4D657821-96E2-4364-B24C-18A044FA819C Q28255877-73941768-667D-463E-A4CF-5E84E7F96C9C Q30843477-668BBE64-BD1E-4D34-BDE4-FA48486A6F8A Q33636374-47A530AA-7423-4752-B06C-C578B7765C5B Q33742711-4CFF5362-EE2B-4756-91F3-7CA7E0058F30 Q33850895-DBF465D4-29F3-49C0-85F2-D35E546854A6 Q34234969-7A64C070-EDDB-4FE2-8E5C-F8B7219D078F Q34508264-98BB8E33-C623-402E-B9CB-F7010F28E793 Q34684165-F154DECA-D8E9-468C-925A-7A34CD4F1F69 Q35640609-B7D56027-5787-4F1A-A2C6-7CAD2D67861B Q36487134-380D3FD7-5D64-47BB-889D-83920F755167 Q36775620-10C66802-2F95-4B00-A5A2-0DE9FE80DB15 Q37256184-4AE50962-4F7B-4D9F-A62E-B3DAAF9C0E4D Q37269247-2E02D284-6C36-4489-AE04-CA5C9ED21CB5 Q37463967-2B30AD10-EA41-42FE-A6EF-57E096FEC543 Q37816447-C939C416-F4F1-4311-864C-45D25236F414 Q37957674-58201DB4-28C0-49F9-B767-0835A33423DC Q38121120-09258675-9C46-4BBB-81B9-985ADA410CB9 Q38158050-66EFE57F-E403-4A77-8A35-C91B8E447767 Q47130088-A036A20F-D71A-4816-B521-8641E3A3AF37 Q47152662-24C531DA-6D6F-49C2-82F1-D9A1F48891EA

P2860

Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression

http://www.wikidata.org/entity/Q36701874

description

2008 nî lūn-bûn

@nan

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

2008年论文

@zh

2008年论文

@zh-cn

name

Therapeutic gene silencing del ...... lateral sclerosis progression

@ast

Therapeutic gene silencing del ...... lateral sclerosis progression

@en

type

label

Therapeutic gene silencing del ...... lateral sclerosis progression

@ast

Therapeutic gene silencing del ...... lateral sclerosis progression

@en

prefLabel

Therapeutic gene silencing del ...... lateral sclerosis progression

@ast

Therapeutic gene silencing del ...... lateral sclerosis progression

@en

P1433

Q36701874-68D14581-04D4-4C0E-AD5D-527ED2E533EC

P1476

Q36701874-059B572E-4381-4A5B-89A8-13E611E24458

P2093

Q36701874-43A0519D-82AF-48B3-9EC4-05D49C0574AA

Q36701874-492D0AC2-0BE1-4916-9A6F-EC5C96C316B1

Q36701874-5E9DB62C-4D5F-454F-B912-FE11C16871B9

Q36701874-6B4F9833-8AF5-45DF-BAFF-55405DCE6879

Q36701874-A771D07A-D974-48F4-A9BD-0DFA8C0DAA9D

Q36701874-BD1609ED-CC1D-455E-914C-70256D4E67F5

Q36701874-C0DFC944-64E0-4404-831F-1246FBA287FE

Q36701874-E2A12ABF-CFC4-4529-BF64-A59F6BE62989

P2860

Q36701874-0F8B5588-7247-43FD-98D8-6B9522292952

Q36701874-2291B816-0887-42CB-9AB4-92B73A4FDD9C

Q36701874-277A87FA-651F-4B0E-AB76-D3D572E18313

Q36701874-285B026B-2144-4499-9542-E91AEB07B1FA

Q36701874-3175DCFA-3930-49F6-A55B-6A9999415601

Q36701874-443DD8F5-D06B-4F5C-97EE-F5EBDD5E87DA

Q36701874-4CA96029-3792-437D-949D-87661433A0C8

Q36701874-5132D56F-B84C-48FE-8757-D2E81C79A572

Q36701874-5233E085-89A0-4661-BC1C-731F42F41DB8

Q36701874-571E9ED0-0957-4344-960F-AB124222A05D

P304

Q36701874-4D54AA40-B983-46B5-8F15-8AA57929804B

P31

Q36701874-E2C74B77-39CB-4436-937F-CC71EAE98887

P356

Q36701874-40665B80-A814-4A4D-AC61-714206AD15B0

P407

Q36701874-095D50CE-E60C-4C17-891F-9D771EDBF996

P433

Q36701874-5B544E0E-D7EF-4559-B2D6-124615C59DB3

P478

Q36701874-EAF46A83-7CB1-40FC-BE53-B4922CA9F89A

P50

Q36701874-2A8B0862-18B5-43E4-BCF7-7802937D7963

P577

Q36701874-22EBCD11-7088-4598-8B12-F5840551D9CD

P5875

Q36701874-87B4570A-718F-4477-AE8B-40DEF4831579

P698

Q36701874-8C77C25F-5585-4920-AA28-D35FD8CC2D2A

P921

Q36701874-0079315B-3217-4AF9-B7A4-59821D9D11DE

Q36701874-A825F9B8-7FEA-44A5-B242-D7848D7FA7FB

P932

Q36701874-726979FC-61F4-48E5-A613-1584671CFC6A

P356

P1433

Journal of Biological Chemistry

P1476

Therapeutic gene silencing del ...... lateral sclerosis progression

@en

P2093

Animesh Ghosh

http://www.w3.org/2001/XMLSchema#string

Hongxia Zhou

http://www.w3.org/2001/XMLSchema#string

Hongyan Wang

http://www.w3.org/2001/XMLSchema#string

Huricha Baigude

http://www.w3.org/2001/XMLSchema#string

Linghua Qiu

http://www.w3.org/2001/XMLSchema#string

Tariq M Rana

http://www.w3.org/2001/XMLSchema#string

Xugang Xia

http://www.w3.org/2001/XMLSchema#string

Zuoshang Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

Onset and progression in inherited ALS determined by motor neurons and microglia

Illuminating the silence: understanding the structure and function of small RNAs

Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication.

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

Instrumentation for neuromodulation.

Mechanism and treatment of motoneuron degeneration in ALS: what have SOD1 mutants told us?

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life.

P304

15845-15852

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M800834200

http://www.w3.org/2001/XMLSchema#string

P407

P433

23

http://www.w3.org/2001/XMLSchema#string

P478

283

http://www.w3.org/2001/XMLSchema#string

P50

P577

2008-03-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5485898

http://www.w3.org/2001/XMLSchema#string

P698

18367449

http://www.w3.org/2001/XMLSchema#string

P921

amyotrophic lateral sclerosis

P932

2414310

http://www.w3.org/2001/XMLSchema#string