The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.

The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.

Item
http://www.wikidata.org/entity/Q34316190
Janus kinase inhibitors: jackpot or potluck?Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617FStructure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinasesMolecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase.Identification of novel SAR properties of the Jak2 small molecule inhibitor G6: significance of the para-hydroxyl orientationAb initio modeling and experimental assessment of Janus Kinase 2 (JAK2) kinase-pseudokinase complex structure.ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activationMolecular insights into regulation of JAK2 in myeloproliferative neoplasmsUncoupling JAK2 V617F activation from cytokine-induced signalling by modulation of JH2 αC helix.A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken.Activating Janus kinase pseudokinase domain mutations in myeloproliferative and other blood cancers.Molecular genetics of myelofibrosis and its associated disease phenotypes.Enhancing specificity in the Janus kinases: a study on the thienopyridine JAK2 selective mechanism combined molecular dynamics simulation.A shift in the salt bridge interaction of residues D620 and E621 mediates the constitutive activation of Jak2-H538Q/K539L.
P2860

The constitutive activation of Jak2-V617F is mediated by a π stacking mechanism involving phenylalanines 595 and 617.

Item
http://www.wikidata.org/entity/Q34316190
description
2010 nî lūn-bûn
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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The constitutive activation of ...... ng phenylalanines 595 and 617.
@ast
The constitutive activation of ...... ng phenylalanines 595 and 617.
@en
The constitutive activation of ...... ng phenylalanines 595 and 617.
@nl
type
label
The constitutive activation of ...... ng phenylalanines 595 and 617.
@ast
The constitutive activation of ...... ng phenylalanines 595 and 617.
@en
The constitutive activation of ...... ng phenylalanines 595 and 617.
@nl
prefLabel
The constitutive activation of ...... ng phenylalanines 595 and 617.
@ast
The constitutive activation of ...... ng phenylalanines 595 and 617.
@en
The constitutive activation of ...... ng phenylalanines 595 and 617.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
The constitutive activation of ...... ing phenylalanines 595 and 617
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932