Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. - Wikidata - awgldk - TriplyDB

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.

http://www.wikidata.org/entity/Q34322167

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Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery Acetylation-dependent regulation of Skp2 function Modulating splicing with small molecular inhibitors of the spliceosome Targeting cancer using KAT inhibitors to mimic lethal knockouts The multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic target Histone acetyltransferases: challenges in targeting bi-substrate enzymes Manipulation of the host protein acetylation network by human immunodeficiency virus type 1 Epigenetics, oestradiol and hippocampal memory consolidation Epigenetics and childhood asthma: current evidence and future research directions KATs in cancer: functions and therapies Mechanisms of epigenetic regulation of leukemia onset and progression Trials with 'epigenetic' drugs: an update Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases Protein lysine acetylation by p300/CBP Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues Epigenetic modulators as therapeutic targets in prostate cancer A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories.A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity Acetylation of retinal histones in diabetes increases inflammatory proteins: effects of minocycline and manipulation of histone acetyltransferase (HAT) and histone deacetylase (HDAC)Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome.Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins.Writers and readers of histone acetylation: structure, mechanism, and inhibition Pneumocystis jirovecii Rtt109, a novel drug target for Pneumocystis pneumonia in immunosuppressed humans Chromatin-regulating proteins as targets for cancer therapy.Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates.A novel functional site in the PB2 subunit of influenza A virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication.Epigenetic changes induced by curcumin and other natural compounds.Perspectives on the discovery of small-molecule modulators for epigenetic processes.Epigenetic regulation of estrogen-dependent memory.Hippocampal histone acetylation regulates object recognition and the estradiol-induced enhancement of object recognition.Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.Histone acetyltransferases: Rising ancient counterparts to protein kinases.Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription.Acetylation-mediated suppression of transcription-independent memory: bidirectional modulation of memory by acetylation PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

P2860

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P2860

Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression.

http://www.wikidata.org/entity/Q34322167

description

2004 nî lūn-bûn

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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2004 թվականի մայիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Journal of Biological Chemistry

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Polyisoprenylated benzophenone ...... alters global gene expression.

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Aarti Ravindran

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Karanam Balasubramanyam

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M Altaf

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Parag P Sadhale

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Radhika A Varier

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Tapas K Kundu

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V Swaminathan

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P2860

Histone-like TAFs within the PCAF histone acetylase complex

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

Acetylation of histones and transcription-related factors

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase

p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation

Steroid receptor coactivator-1 is a histone acetyltransferase

Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

The PCAF acetylase complex as a potential tumor suppressor

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33716-33726

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8550126

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15155757

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