Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. - Wikidata - awgldk - TriplyDB

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.

http://www.wikidata.org/entity/Q34329880

about

Novel protective effects of histone deacetylase inhibition on stroke and white matter ischemic injury Chemobrain: a critical review and causal hypothesis of link between cytokines and epigenetic reprogramming associated with chemotherapy Epigenetic mechanisms in mood disorders: targeting neuroplasticity Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests Maternal Exposure of Rats to Isoflurane during Late Pregnancy Impairs Spatial Learning and Memory in the Offspring by Up-Regulating the Expression of Histone Deacetylase 2.Substituted tetrazoles as multipurpose screening compounds.NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain.Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance.SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue.Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease.Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan Epigenetics: a novel therapeutic approach for the treatment of Alzheimer's disease Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells.Transcriptional and epigenetic regulation of Hebbian and non-Hebbian plasticity.Epigenetic regulation of memory formation and maintenance.Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation.Prospects for the development of epigenetic drugs for CNS conditions.Cinnamamide Derivatives for Central and Peripheral Nervous System Disorders--A Review of Structure-Activity Relationships.Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.Apigenin Ameliorates Post-Stroke Cognitive Deficits in Rats Through Histone Acetylation-Mediated Neurochemical Alterations.Epigenetic stability in the adult mouse cortex under conditions of pharmacologically induced histone acetylation.M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.Prospects for Medications to Reverse Causative Epigenetic Processes in Neuropsychiatry Disorders.Early life stress-induced histone acetylations correlate with activation of the synaptic plasticity genes Arc and Egr1 in the mouse hippocampus.Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone.WNT/β-Catenin Pathway and Epigenetic Mechanisms Regulate the Pitt-Hopkins Syndrome and Schizophrenia Risk Gene TCF4.Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.

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P2860

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.

http://www.wikidata.org/entity/Q34329880

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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J.NEUROPHARM.2012.06.043

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Neuropharmacology

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Crebinostat: a novel cognitive ...... atin-mediated neuroplasticity.

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P2093

Balaram Ghosh

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Chelsea E Groves Kuhnle

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Daniel M Fass

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Douglas D Barker

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Krista M Hennig

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Li-Huei Tsai

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Nadine F Joseph

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Ralph Mazitschek

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Stephen J Haggarty

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Stuart L Schreiber

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

HDAC2 negatively regulates memory formation and synaptic plasticity.

An epigenetic blockade of cognitive functions in the neurodegenerating brain

The dynamic role of beta-catenin in synaptic plasticity

Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides

Lysine acetylation targets protein complexes and co-regulates major cellular functions

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome

The multifunctional role of the co-activator CBP in transcriptional regulation

CBP histone acetyltransferase activity is a critical component of memory consolidation

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81-96

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10.1016/J.NEUROPHARM.2012.06.043

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64

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Ralph Mazitschek

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2012-07-04T00:00:00Z

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22771460

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neuroplasticity

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3447535

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