SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.
about
HDAC and HDAC Inhibitor: From Cancer to Cardiovascular DiseasesHistone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell ViabilityIn vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs.Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.Epigenetic memory: the Lamarckian brainPET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain.Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer CellsEpigenetic drug discovery for Alzheimer's disease.Animal models of Huntington's disease for translation to the clinic: best practices.Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma.Inhibitors of histone deacetylases enhance neurotoxicity of DNA damageHDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors.Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memoryFTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.Translational gap in ongoing clinical trials for glioma.Visual experience dependent regulation of neuronal structure and function by histone deacetylase 1 in developing Xenopus tectum in vivo.Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease.GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia.
P2860
Q26766640-1549058B-1876-4623-9168-1C1CB6219F00Q27679266-50D5E785-3D3F-4762-A325-1234760A3A29Q30591009-B31A66F8-4F9D-4B4C-A7C0-2AA939F95DD4Q33918201-B102DAB2-CB19-4939-B444-0F82F1B47681Q34323841-B3746A8A-5B21-4BFA-A76B-B88BA43B6BD8Q34343350-F588EDDD-2E63-49F1-AD87-0146DA15EB08Q34395031-FFB1E46F-C079-4A73-BCBB-EBF364A8B0F7Q36746950-6812C9C1-7452-4A2E-AAF8-5C782BD30887Q38225708-516199DD-3223-4BCA-82D6-FFE49AD31ED0Q38248687-E93CA24A-C915-4D95-B5E9-6830F849048DQ40078610-CCAC3135-EF53-4887-9C87-2EF820EE13EEQ41851979-F462AA6C-0863-4111-A13B-824C034109E9Q41879366-F7F69D9C-5BF0-4D43-8410-44C1CBB299F2Q42314505-3F8D490D-FA35-4764-8D40-14567F9F3A1FQ42803814-A0854783-B886-4FB6-A7A2-BC2CF53885B5Q46956989-1A3DE216-7785-4A85-B5C3-6E7061A676D8Q47843990-BCF82EBC-02A8-4A03-A33D-3753FAD523FEQ48002716-1D904A25-96E5-4CE7-836D-9B08E8086D30Q48107874-8777A398-E749-46E1-81A0-4A15E153110BQ48379148-ACC360B9-2A49-46BA-B710-075681DCB94DQ48517175-3F0918FC-0136-4FD6-85D5-82A9032CA6BEQ53428761-B359C36E-F6C9-44CC-8F80-9007DA322AC5
P2860
SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
SAHA enhances synaptic functio ...... and does not impact cognition.
@ast
SAHA enhances synaptic functio ...... and does not impact cognition.
@en
SAHA enhances synaptic functio ...... and does not impact cognition.
@nl
type
label
SAHA enhances synaptic functio ...... and does not impact cognition.
@ast
SAHA enhances synaptic functio ...... and does not impact cognition.
@en
SAHA enhances synaptic functio ...... and does not impact cognition.
@nl
prefLabel
SAHA enhances synaptic functio ...... and does not impact cognition.
@ast
SAHA enhances synaptic functio ...... and does not impact cognition.
@en
SAHA enhances synaptic functio ...... and does not impact cognition.
@nl
P2093
P2860
P1433
P1476
SAHA enhances synaptic functio ...... and does not impact cognition.
@en
P2093
Dani Brunner
Emer Leahy
Emile Plise
Emily V Sabath
Jesse E Hanson
Kimberly Scearce-Levie
Lichuan Liu
Pascal Steiner
Qiang Zhou
P2860
P304
P356
10.1371/JOURNAL.PONE.0069964
P407
P577
2013-07-26T00:00:00Z