Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.
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The RAG1 N-terminal domain is an E3 ubiquitin ligaseThe metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombinationThe plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombinationPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemAutoubiquitylation of the V(D)J recombinase protein RAG1The mouse immunoglobulin heavy chain V-D intergenic sequence contains insulators that may regulate ordered V(D)J recombinationAnalysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.The RAG proteins in V(D)J recombination: more than just a nuclease.Deletion of the RAG2 C terminus leads to impaired lymphoid development in miceMobilization of RAG-generated signal ends by transposition and insertion in vivoCoupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegationThe C-terminal portion of RAG2 protects against transposition in vitroRegulation of RAG1/RAG2-mediated transposition by GTP and the C-terminal region of RAG2Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Artemis sheds new light on V(D)J recombination.How to keep V(D)J recombination under control.Role of RAG1 autoubiquitination in V(D)J recombination.Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4.Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.RAG: a recombinase diversified.Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins.RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation.ATP-dependent remodeling by SWI/SNF and ISWI proteins stimulates V(D)J cleavage of 5 S arrays.
P2860
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P2860
Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@ast
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@en
type
label
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@ast
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@en
prefLabel
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@ast
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@en
P2093
P2860
P356
P1433
P1476
Dual role of RAG2 in V(D)J rec ...... n of ordered Ig gene assembly.
@en
P2093
G A Rathbun
M A Oettinger
P2860
P304
P356
10.1093/EMBOJ/17.16.4881
P407
P577
1998-08-01T00:00:00Z