Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. - Wikidata - awgldk - TriplyDB

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

http://www.wikidata.org/entity/Q34333731

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ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair DNA-PK: a dynamic enzyme in a versatile DSB repair pathway XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV Role of non-homologous end joining in V(D)J recombination Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.A noncatalytic function of the ligation complex during nonhomologous end joining.Nonhomologous end joining: a good solution for bad ends Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Cooperative assembly of a protein-DNA filament for nonhomologous end joining Choosing the right path: does DNA-PK help make the decision?Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair.Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair DNA double strand break repair via non-homologous end-joining.Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions Repair of double-strand breaks by end joining.The spatial organization of non-homologous end joining: from bridging to end joining.Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.Progressive cerebellar atrophy and polyneuropathy: expanding the spectrum of PNKP mutations.Characterization of DNA Substrate Binding to the Phosphatase Domain of the DNA Repair Enzyme Polynucleotide Kinase/Phosphatase Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.Nepenthesin from monkey cups for hydrogen/deuterium exchange mass spectrometry.Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA.

P2860

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P2860

Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining.

http://www.wikidata.org/entity/Q34333731

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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Dual modes of interaction betw ...... for nonhomologous end joining.

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JBC.M109.058719

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Journal of Biological Chemistry

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Dual modes of interaction betw ...... for nonhomologous end joining.

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P2093

Angela E Zolner

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Dale A Ramsden

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David W Litchfield

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Meiling Lu

http://www.w3.org/2001/XMLSchema#string

Mesfin Fanta

http://www.w3.org/2001/XMLSchema#string

Michael Weinfeld

http://www.w3.org/2001/XMLSchema#string

Nasser Tahbaz

http://www.w3.org/2001/XMLSchema#string

Rajam S Mani

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Shujuan Fang

http://www.w3.org/2001/XMLSchema#string

Susan P Lees-Miller

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P2860

Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3'-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage

Molecular characterization of a human DNA kinase

Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining

Ku recruits the XRCC4-ligase IV complex to DNA ends

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

P304

37619-37629

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scholarly article

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10.1074/JBC.M109.058719

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P407

P433

48

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P478

285

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2010-09-17T00:00:00Z

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20852255

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2988367

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