Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
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Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteinsSustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorderMouse models for radiation-induced cancersPU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AMLMouse models for efficacy testing of agents against radiation carcinogenesis—a literature reviewPU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cellsIn silico regulatory analysis for exploring human disease progression.Systemic inoculation of Escherichia coli causes emergency myelopoiesis in zebrafish larval caudal hematopoietic tissueFrequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells.Ski can negatively regulates macrophage differentiation through its interaction with PU.1.Sweating the small stuff: microRNAs and genetic changes define pancreatic cancer.Radiation-induced myeloid leukemia in murine models.Repression of Id2 expression by Gfi-1 is required for B-cell and myeloid developmentAssociation of a functional polymorphism in the 3'-untranslated region of SPI1 with systemic lupus erythematosus.Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia.Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production.The significance of low PU.1 expression in patients with acute promyelocytic leukemia.Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia.Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemiaTranscriptional dysregulation during myeloid transformation in AML.Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.Molecular characterisation of murine acute myeloid leukaemia induced by 56Fe ion and 137Cs gamma ray irradiation.Live cell detection of chromosome 2 deletion and Sfpi1/PU1 loss in radiation-induced mouse acute myeloid leukaemiaThe role of aberrant transcription factor in the progression of chronic myeloid leukemia.PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia.Positive feedback between PU.1 and the cell cycle controls myeloid differentiationThe transcription factor PU.1 is a critical regulator of cellular communication in the immune system.PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation.Down-regulation of hematopoiesis master regulator PU.1 via aberrant methylation in chronic myeloid leukemia.PU.1 activates transcription of SHP-1 gene in hematopoietic cells.Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia.Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.Suppression of Pu.1 function results in expanded myelopoiesis in zebrafish.Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells.Pin1-mediated prolyl isomerization of Runx1 affects PU.1 expression in pre-monocytes.Assessment of HDACi-Induced Protein Cleavage by Caspases.Tracking preleukemic cells in vivo to reveal the sequence of molecular events in radiation leukemogenesis.CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia.
P2860
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P2860
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@ast
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@en
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@nl
type
label
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@ast
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@en
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@nl
prefLabel
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@ast
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@en
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@nl
P2093
P2860
P356
P1476
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
@en
P2093
Aleksandar Dakic
Sandra Mifsud
Stephen Nutt
P2860
P304
P356
10.1073/PNAS.0510616103
P407
P577
2006-01-23T00:00:00Z