Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. - Wikidata - awgldk - TriplyDB

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

http://www.wikidata.org/entity/Q34336290

about

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia Chloride channels as drug targets.The ABC protein turned chloride channel whose failure causes cystic fibrosis Predominant constitutive CFTR conductance in small airways A functional CFTR assay using primary cystic fibrosis intestinal organoids Steviol reduces MDCK Cyst formation and growth by inhibiting CFTR channel activity and promoting proteasome-mediated CFTR degradation Putative anion transporter-1 (Pat-1, Slc26a6) contributes to intracellular pH regulation during H+-dipeptide transport in duodenal villous epithelium Identification of resveratrol oligomers as inhibitors of cystic fibrosis transmembrane conductance regulator by high-throughput screening of natural products from chinese medicinal plants Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy Inhibition of cAMP-activated intestinal chloride secretion by diclofenac: cellular mechanism and potential application in cholera Small-molecule inhibitors of the cystic fibrosis transmembrane conductance regulator increase pancreatic endocrine cell development in rat and mouse The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.CFTR-deficient pigs display peripheral nervous system defects at birth.Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2 Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis Comparative Effects of Chloride Channel Inhibitors on LRRC8/VRAC-Mediated Chloride Conductance.Bacterial Sphingomyelinase is a State-Dependent Inhibitor of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR)Native small airways secrete bicarbonate.CFTR-mediated halide transport in phagosomes of human neutrophils.Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway.Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR.CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia The block of CFTR by scorpion venom is state-dependent On the mechanism of CFTR inhibition by a thiazolidinone derivative.Cystic fibrosis transmembrane conductance regulator chloride channel blockers: Pharmacological, biophysical and physiological relevance.FOXO1 content is reduced in cystic fibrosis and increases with IGF-I treatment.The mitochondrial complex I activity is reduced in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.The interaction of gut microbes with host ABC transporters.Listeria monocytogenes exploits cystic fibrosis transmembrane conductance regulator (CFTR) to escape the phagosome.CFTR inhibitors.Protection against oxidative stress in beta thalassemia/hemoglobin E erythrocytes by inhibitors of glutathione efflux transporters.Loss of anion transport without increased sodium absorption characterizes newborn porcine cystic fibrosis airway epithelia.Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium.

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P2860

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy.

http://www.wikidata.org/entity/Q34336290

description

2004 nî lūn-bûn

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2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի օգոստոսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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type

label

Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

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P1433

The Journal of General Physiology

P1476

Discovery of glycine hydrazide ...... nalysis, and in vivo efficacy.

@en

P2093

A S Verkman

http://www.w3.org/2001/XMLSchema#string

Alessandro Taddei

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Chatchai Muanprasat

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Danieli Salinas

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Luis J V Galietta

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N D Sonawane

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P2860

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

Synthesis and antitubercular activity of N-(2-naphthyl)glycine hydrazide analogues

Mechanism and cellular applications of a green fluorescent protein-based halide sensor.

Permeation through the CFTR chloride channel.

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

Syntheses and anti-inflammatory activities of substituted arylamino-(N'-benzylidene)acetohydrazides and derivatives.

CFTR pharmacology and its role in intestinal fluid secretion.

Probing an open CFTR pore with organic anion blockers

Selective open-channel block of Shaker (Kv1) potassium channels by s-nitrosodithiothreitol (SNDTT)

Cooperative block of the plant endomembrane ion channel by ruthenium red.

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125-137

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10.1085/JGP.200409059

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2

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124

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8431503

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15277574

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2229623

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