A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.
about
Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathwaysNew developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma2-Hydoxyglutarate: D/Riving Pathology in gLiomaSRapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cellsInterplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approachesRegulation of substrate utilization by the mitochondrial pyruvate carrierTargeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachoneSelenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells.Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy.Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics.Impending Impact of Molecular Pathology on Classifying Adult Diffuse Gliomas.Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions.Glutaminolysis as a target for cancer therapy.Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype.Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.Gene alterations and epigenetic changes in intrahepatic cholangiocarcinoma.Perspectives on investigational drugs and immunotherapies for glioblastoma.Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration-Approved Drugs.Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays[18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition.Wild-type and mutated IDH1/2 enzymes and therapy responses.Glutamine Metabolism in Gliomas.
P2860
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P2860
A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor.
description
2014 nî lūn-bûn
@nan
2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@ast
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@en
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@nl
type
label
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@ast
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@en
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@nl
prefLabel
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@ast
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@en
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@nl
P2093
P2860
P1433
P1476
A high-throughput fluorimetric ...... st as a glutaminase inhibitor.
@en
P2093
Adnan Elhammali
David Piwnica-Worms
Jan Crowley
Jayne Marasa
Joseph E Ippolito
Lynne Collins
P2860
P304
P356
10.1158/2159-8290.CD-13-0572
P577
2014-04-16T00:00:00Z