Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
about
Cryoelectron tomography of HIV-1 envelope spikes: further evidence for tripod-like legsA Conformational Switch in Human Immunodeficiency Virus gp41 Revealed by the Structures of Overlapping Epitopes Recognized by Neutralizing AntibodiesInteractions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing ActivityBroad and potent neutralization of HIV-1 by a gp41-specific human antibodyStructure-Based Design of a Protein Immunogen that Displays an HIV-1 gp41 Neutralizing EpitopeAutoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10Max Bergmann lecture protein epitope mimetics in the age of structural vaccinologyAppreciating HIV type 1 diversity: subtype differences in Env.An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid beta peptides.Antigenic characteristics of rhinovirus chimeras designed in silico for enhanced presentation of HIV-1 gp41 epitopes [corrected].4E10-resistant HIV-1 isolated from four subjects with rare membrane-proximal external region polymorphismsAntibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralizationAutomated synthesis of backbone protected peptides.HIV p24 as scaffold for presenting conformational HIV Env antigens.Designing a soluble near full-length HIV-1 gp41 trimer.Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate.Assisted peptide folding by surface pattern recognition.The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes.Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses.Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.Conditional trimerization and lytic activity of HIV-1 gp41 variants containing the membrane-associated segments.A High Throughput Protein Microarray Approach to Classify HIV Monoclonal Antibodies and Variant Antigens.Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategyNeutralizing epitopes in the membrane-proximal external region of HIV-1 gp41 are influenced by the transmembrane domain and the plasma membrane.Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzeesAssociation of enhanced HIV-1 neutralization by a single Y681H substitution in gp41 with increased gp120-CD4 interaction and macrophage infectivity.Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10.Immunogenic properties of a trimeric gp41-based immunogen containing an exposed membrane-proximal external regionWash-free, electrochemical platform for the quantitative, multiplexed detection of specific antibodiesCrystallographic Identification of Lipid as an Integral Component of the Epitope of HIV Broadly Neutralizing Antibody 4E10.The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine designHIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.Inhibition of HIV-1 entry by antibodies: potential viral and cellular targetsPilot study on the immunogenicity of paired Env immunogens from mother-to-child transmitted HIV-1 isolates.A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.The broadly neutralizing anti-human immunodeficiency virus type 1 4E10 monoclonal antibody is better adapted to membrane-bound epitope recognition and blocking than 2F5.Modulating immunogenic properties of HIV-1 gp41 membrane-proximal external region by destabilizing six-helix bundle structure.
P2860
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P2860
Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody.
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structure-function analysis of ...... iciency virus type 1 antibody.
@ast
Structure-function analysis of ...... iciency virus type 1 antibody.
@en
Structure-function analysis of ...... iciency virus type 1 antibody.
@nl
type
label
Structure-function analysis of ...... iciency virus type 1 antibody.
@ast
Structure-function analysis of ...... iciency virus type 1 antibody.
@en
Structure-function analysis of ...... iciency virus type 1 antibody.
@nl
prefLabel
Structure-function analysis of ...... iciency virus type 1 antibody.
@ast
Structure-function analysis of ...... iciency virus type 1 antibody.
@en
Structure-function analysis of ...... iciency virus type 1 antibody.
@nl
P2093
P2860
P1433
P1476
Structure-function analysis of ...... iciency virus type 1 antibody.
@en
P2093
Dennis R Burton
Florence M Brunel
Josh D Nelson
Michael B Zwick
Philip E Dawson
Rosa M F Cardoso
P2860
P304
P356
10.1128/JVI.80.4.1680-1687.2006
P407
P577
2006-02-01T00:00:00Z