Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
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The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosisTuberculosis drug discovery in the post-post-genomic eraThe Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis.New insights into TB physiology suggest untapped therapeutic opportunitiesA high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosisA Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal PeptidaseSelective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory siteTarget-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivoRegulated Expression Systems for Mycobacteria and Their ApplicationsAssessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitorsMycobacterium tuberculosis metabolismTarget mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteriaAltered Proteome of Burkholderia pseudomallei Colony Variants Induced by Exposure to Human Lung Epithelial CellsThe tuberculosis drug discovery and development pipeline and emerging drug targets.Genetic Approaches to Facilitate Antibacterial Drug Development.Reaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosisTherapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence.Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis.Tuberculosis drug discovery and emerging targets.Future target-based drug discovery for tuberculosis?The future for early-stage tuberculosis drug discoveryPantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants.Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.N-Acetylglucosamine-1-phosphate transferase, WecA, as a validated drug target in Mycobacterium tuberculosis.Current challenges in drug discovery for tuberculosis.Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes.Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents.Target-based whole-cell screening by ¹H NMR spectroscopyOptimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency AnalysisTargeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Construction of conditional knockdown mutants in mycobacteria.Expanding benzoxazole based inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor structure-activity as potential anti-tuberculosis agents.Emerging drugs and drug targets against tuberculosis.Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological ActivityDeath of Mycobacterium tuberculosis by L-arginine starvation
P2860
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P2860
Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Pathway-selective sensitizatio ...... get-based whole-cell screening
@ast
Pathway-selective sensitizatio ...... get-based whole-cell screening
@en
Pathway-selective sensitizatio ...... get-based whole-cell screening
@nl
type
label
Pathway-selective sensitizatio ...... get-based whole-cell screening
@ast
Pathway-selective sensitizatio ...... get-based whole-cell screening
@en
Pathway-selective sensitizatio ...... get-based whole-cell screening
@nl
prefLabel
Pathway-selective sensitizatio ...... get-based whole-cell screening
@ast
Pathway-selective sensitizatio ...... get-based whole-cell screening
@en
Pathway-selective sensitizatio ...... get-based whole-cell screening
@nl
P2093
P2860
P50
P1476
Pathway-selective sensitizatio ...... get-based whole-cell screening
@en
P2093
Alvin W Hung
Anuradha Kumar
Chris Abell
David R Sherman
Helena I M Boshoff
Suzana Savvi
P2860
P304
P356
10.1016/J.CHEMBIOL.2012.05.020
P577
2012-07-01T00:00:00Z