Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing.
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CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motifPhosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonucleaseStructure and thermodynamics of a conserved U2 snRNA domain from yeast and humanEvidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast.Central region of the human splicing factor Hprp3p interacts with Hprp4pA ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formationMetal ion catalysis during group II intron self-splicing: parallels with the spliceosomeTailoring of membrane proteins by alternative splicing of pre-mRNA.The role of exon sequences in C complex spliceosome structureRNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Alternative promoters influence alternative splicing at the genomic level.Nuclear expression of a group II intron is consistent with spliceosomal intron ancestry.Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutationsEvolution of group II intronsProximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.Characterization of the catalytic activity of U2 and U6 snRNAsNew tertiary constraints between the RNA components of active yeast spliceosomes: a photo-crosslinking study.RNA catalyses nuclear pre-mRNA splicingRNA-protein interactions that regulate pre-mRNA splicing.Use of 1,2,4-dithiazolidine-3,5-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides.Branch-point attack in group II introns is a highly reversible transesterification, providing a potential proofreading mechanism for 5'-splice site selection.A general and efficient approach for the construction of RNA oligonucleotides containing a 5'-phosphorothiolate linkage.Evolution of introns in the archaeal worldIdentification of phosphate oxygens that are important for self-cleavage activity of the HDV ribozyme by phosphorothioate substitution interference analysis.Single-molecule analysis of protein-free U2-U6 snRNAs.Fluorescence and solution NMR study of the active site of a 160-kDa group II intron ribozyme.Group II introns: mobile ribozymes that invade DNA.Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.Rational evolution of Cd2+-specific DNAzymes with phosphorothioate modified cleavage junction and Cd2+ sensing.Three recognition events at the branch-site adenine.Human MFAP1 is a cryptic ortholog of the Saccharomyces cerevisiae Spp381 splicing factorA minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract.Inactivation of the UGPase1 gene causes genic male sterility and endosperm chalkiness in rice (Oryza sativa L.).Free energy landscapes of RNA/RNA complexes: with applications to snRNA complexes in spliceosomes.Single-molecule colocalization FRET evidence that spliceosome activation precedes stable approach of 5' splice site and branch site.
P2860
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P2860
Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing.
description
1993 nî lūn-bûn
@nan
1993 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@ast
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@en
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@nl
type
label
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@ast
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@en
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@nl
prefLabel
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@ast
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@en
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@nl
P356
P1433
P1476
Evidence for two active sites ...... hemistry of pre-mRNA splicing.
@en
P2093
P2888
P304
P356
10.1038/365364A0
P407
P577
1993-09-01T00:00:00Z
P5875
P6179
1019468016