An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase
about
Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesionThe morph server: a standardized system for analyzing and visualizing macromolecular motions in a database framework.Geometry of interplanar residue contacts in protein structuresMolecular dynamics simulations suggest that electrostatic funnel directs binding of Tamiflu to influenza N1 neuraminidases.Cation-pi interactions as determinants for binding of the compatible solutes glycine betaine and proline betaine by the periplasmic ligand-binding protein ProX from Escherichia coliMechanisms of cholinesterase inhibition by inorganic mercuryMolecular Basis of Prodrug Activation by Human Valacyclovirase, an -Amino Acid Ester HydrolaseShoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallographyAcetylcholinesterase: From 3D structure to functionBackdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulationsMolecular characterization of monoclonal antibodies that inhibit acetylcholinesterase by targeting the peripheral site and backdoor regionSubstrate tunnels in enzymes: structure-function relationships and computational methodologyContribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesteraseArsenic binding to proteinsA server and database for dipole moments of proteins.Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase.PHEMTO: protein pH-dependent electric moment tools.Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: a new binding site detected by NMR spectroscopy.Sub-terahertz spectroscopy reveals that proteins influence the properties of water at greater distances than previously detected.Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homologNovel human butyrylcholinesterase variants: toward organophosphonate detoxicationElectrostatic potentials and electrostatic interaction energies of rat cytochrome b5 and a simulated anion-exchange adsorbent surfaceAnalysis of a 10-ns molecular dynamics simulation of mouse acetylcholinesterase.The dynamics of ligand barrier crossing inside the acetylcholinesterase gorgeLong route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesteraseMultiple advantages of capillary zone electrophoresis for exploring protein conformational stability.Kinetics of human serum butyrylcholinesterase inhibition by a novel experimental Alzheimer therapeutic, dihydrobenzodioxepine cymserine.Electrostatic steering at acetylcholine binding sitesCrystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.Marine AChE inhibitors isolated from Geodia barretti: natural compounds and their synthetic analogs.Conformation gating as a mechanism for enzyme specificity.Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor designState-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substituted cysteines in the M2 segment of the alpha subunit.Computational Studies on Acetylcholinesterases.Electrostatics and the ion selectivity of ligand-gated channels.A modular treatment of molecular traffic through the active site of cholinesterase.Nanosecond dynamics of acetylcholinesterase near the active center gorge.Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase.Probing the active center gorge of acetylcholinesterase by fluorophores linked to substituted cysteines.
P2860
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P2860
An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
name
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@ast
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@en
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@nl
type
label
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@ast
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@en
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@nl
prefLabel
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@ast
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@en
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@nl
P2093
P2860
P356
P1476
An electrostatic mechanism for ...... gorge of acetylcholinesterase
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.11.5128
P407
P577
1993-06-01T00:00:00Z