Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.
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Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and designThe 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitorsCrystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assemblyContribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesteraseIn silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of beta-amyloid plaques associated with Alzheimer's disease.Applications of integrated data mining methods to exploring natural product space for acetylcholinesterase inhibitors.Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthdayLong route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesteraseMultiple advantages of capillary zone electrophoresis for exploring protein conformational stability.LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY.The structure-function relationships in Drosophila neurotactin show that cholinesterasic domains may have adhesive properties.Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus.MolAxis: efficient and accurate identification of channels in macromoleculesAllosteric control of acetylcholinesterase catalysis by fasciculin.Mouse acetylcholinesterase unliganded and in complex with huperzine A: a comparison of molecular dynamics simulations.Customizing scoring functions for docking.Hydration change during the aging of phosphorylated human butyrylcholinesterase: importance of residues aspartate-70 and glutamate-197 in the water network as probed by hydrostatic and osmotic pressures.Pressure and heat inactivation of recombinant human acetylcholinesterase. Importance of residue E202 for enzyme stability.Engineering of a monomeric and low-glycosylated form of human butyrylcholinesterase: expression, purification, characterization and crystallization.Expression and activity of mutants of fasciculin, a peptidic acetylcholinesterase inhibitor from mamba venom.Structure-functional effects of ethanol on Drosophila melanogaster acetylcholinesterase probed by kinetic studies with substrate and inhibitors.Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer's disease.Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function.Structural modifications of the omega loop in human acetylcholinesterase.
P2860
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P2860
Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年学术文章
@wuu
1994年学术文章
@zh-cn
1994年学术文章
@zh-hans
1994年学术文章
@zh-my
1994年学术文章
@zh-sg
1994年學術文章
@yue
1994年學術文章
@zh
1994年學術文章
@zh-hant
name
Structure and dynamics of the ...... ion and X-ray crystallography.
@ast
Structure and dynamics of the ...... ion and X-ray crystallography.
@en
type
label
Structure and dynamics of the ...... ion and X-ray crystallography.
@ast
Structure and dynamics of the ...... ion and X-ray crystallography.
@en
prefLabel
Structure and dynamics of the ...... ion and X-ray crystallography.
@ast
Structure and dynamics of the ...... ion and X-ray crystallography.
@en
P2093
P2860
P356
P1433
P1476
Structure and dynamics of the ...... ion and X-ray crystallography.
@en
P2093
P2860
P304
P356
10.1002/PRO.5560030204
P577
1994-02-01T00:00:00Z