Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.
about
PALB2 regulates recombinational repair through chromatin association and oligomerizationThe molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorUse of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitmentSite-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptationDynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activityPph3 dephosphorylation of Rad53 is required for cell recovery from MMS-induced DNA damage in Candida albicans.An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control.Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends.Oligomerization of MDC1 protein is important for proper DNA damage responseFunctional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.Colocalization of Mec1 and Mrc1 is sufficient for Rad53 phosphorylation in vivo.Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 ActivityDimerization Mediated by a Divergent Forkhead-associated Domain Is Essential for the DNA Damage and Spindle Functions of Fission Yeast Mdb1.Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Similarities and differences between "uncapped" telomeres and DNA double-strand breaks.Biology of telomeres: lessons from budding yeast.Coupling end resection with the checkpoint response at DNA double-strand breaks.53BP1 promotes ATM activity through direct interactions with the MRN complex.A cell cycle-independent mode of the Rad9-Dpb11 interaction is induced by DNA damage.The Saccharomyces cerevisiae RAD9, RAD17 and RAD24 genes are required for suppression of mutagenic post-replicative repair during chronic DNA damage.Replication checkpoint: tuning and coordination of replication forks in s phase.Dissection of Rad9 BRCT domain function in the mitotic checkpoint response to telomere uncapping.Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.
P2860
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P2860
Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization.
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
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2009年论文
@wuu
name
Maintenance of the DNA-damage ...... iator protein oligomerization.
@ast
Maintenance of the DNA-damage ...... iator protein oligomerization.
@en
Maintenance of the DNA-damage ...... iator protein oligomerization.
@nl
type
label
Maintenance of the DNA-damage ...... iator protein oligomerization.
@ast
Maintenance of the DNA-damage ...... iator protein oligomerization.
@en
Maintenance of the DNA-damage ...... iator protein oligomerization.
@nl
prefLabel
Maintenance of the DNA-damage ...... iator protein oligomerization.
@ast
Maintenance of the DNA-damage ...... iator protein oligomerization.
@en
Maintenance of the DNA-damage ...... iator protein oligomerization.
@nl
P2860
P1433
P1476
Maintenance of the DNA-damage ...... iator protein oligomerization.
@en
P2093
Steven S Foster
Takehiko Usui
P2860
P304
P356
10.1016/J.MOLCEL.2008.12.022
P50
P577
2009-01-01T00:00:00Z