Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
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Building a ninefold symmetrical barrel: structural dissections of centriole assemblyp53 protects against genome instability following centriole duplication failureDNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster.The centriole duplication cycle.Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.Autoinhibition and relief mechanism for Polo-like kinase 4.Pom1 gradient buffering through intermolecular auto-phosphorylation.CRL4WDR1 Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei.A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4Casein kinase II is required for proper cell division and acts as a negative regulator of centrosome duplication in Caenorhabditis elegans embryos.Polo-like kinases: structural variations lead to multiple functions.Binding of STIL to Plk4 activates kinase activity to promote centriole assemblyNovel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy.NEK7 is required for G1 progression and procentriole formation.Expression, purification and preliminary crystallographic analysis of the cryptic polo-box domain of Caenorhabditis elegans ZYG-1.A key centriole assembly interaction interface between human PLK4 and STIL appears to not be conserved in flies.Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis.Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation.Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.PLK4: a link between centriole biogenesis and cancer.Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma.PLK4 is essential for meiotic resumption in mouse oocytes.Once and only once: mechanisms of centriole duplication and their deregulation in disease.A homeostatic clock sets daughter centriole size in flies.An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.A novel role for Plk4 in regulating cell spreading and motility.Targeting the cell cycle in breast cancer: towards the next phaseRevisiting Centrioles in Nematodes-Historic Findings and Current TopicsCentrosomal and Non-Centrosomal Microtubule-Organizing Centers (MTOCs) in
P2860
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P2860
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
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2013 nî lūn-bûn
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2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@ast
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@en
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@nl
type
label
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@ast
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@en
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@nl
prefLabel
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@ast
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@en
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.
@nl
P2093
P50
P1433
P1476
Regulation of autophosphorylation controls PLK4 self-destruction and centriole number
@en
P2093
Ana Pimenta-Marques
Ana Rodrigues-Martins
Daniela Brito
Inês Bento
Inês Cunha-Ferreira
Samuel Gilberto
P304
P356
10.1016/J.CUB.2013.09.037
P407
P50
P577
2013-10-31T00:00:00Z