Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.
about
Molecular organization and dynamics of the melatonin MT₁ receptor/RGS20/G(i) protein complex reveal asymmetry of receptor dimers for RGS and G(i) couplingAbundance and stability of complexes containing inactive G protein-coupled receptors and G proteinsGene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulationHeterotrimeric G proteins precouple with G protein-coupled receptors in living cells.Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.Direct observation of individual KCNQ1 potassium channels reveals their distinctive diffusive behavior.HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes.Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity.Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets.The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels.Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q.An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and traffickingActive Galpha(q) subunits and M3 acetylcholine receptors promote distinct modes of association of RGS2 with the plasma membrane.Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium HandlingReduced-order modelling of biochemical networks: application to the GTPase-cycle signalling moduleR4 RGS proteins: regulation of G-protein signaling and beyond.A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptorsThe role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexesMixed-integer nonlinear optimisation approach to coarse-graining biochemical networks.Structure, function, and localization of Gβ5-RGS complexes.Impact of fusion to Gα(i2) and co-expression with RGS proteins on pharmacological properties of human cannabinoid receptors CB₁R and CB₂R.Do caveolae have a role in the fidelity and dynamics of receptor activation of G-protein-gated inwardly rectifying potassium channels?The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7A role for RGS10 in beta-adrenergic modulation of G-protein-activated K+ (GIRK) channel current in rat atrial myocytes.Kinetic diversity in G-protein-coupled receptor signalling.Kinetic, pharmacological and activity-dependent separation of two Ca2+ signalling pathways mediated by type 1 metabotropic glutamate receptors in rat Purkinje neurones.RGS3 and RGS4 differentially associate with G protein-coupled receptor-Kir3 channel signaling complexes revealing two modes of RGS modulation. Precoupling and collision coupling.RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo.Differential effects of inhibitory G-protein isoforms on G-protein gated inwardly rectifying K+ currents in adult murine atria.
P2860
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P2860
Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Regulators of G-protein signal ...... signaling activation kinetics.
@ast
Regulators of G-protein signal ...... signaling activation kinetics.
@en
Regulators of G-protein signal ...... signaling activation kinetics.
@nl
type
label
Regulators of G-protein signal ...... signaling activation kinetics.
@ast
Regulators of G-protein signal ...... signaling activation kinetics.
@en
Regulators of G-protein signal ...... signaling activation kinetics.
@nl
prefLabel
Regulators of G-protein signal ...... signaling activation kinetics.
@ast
Regulators of G-protein signal ...... signaling activation kinetics.
@en
Regulators of G-protein signal ...... signaling activation kinetics.
@nl
P2093
P2860
P356
P1476
Regulators of G-protein signal ...... signaling activation kinetics.
@en
P2093
Amy Benians
Andrew Tinker
Muriel Nobles
Sherif Hosny
P2860
P304
13383-13394
P356
10.1074/JBC.M410163200
P407
P577
2005-01-27T00:00:00Z