about
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleusWNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrateEssential role of PDK1 in regulating cell size and development in miceRapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cellsTherapeutic Implications of Targeting AKT Signaling in MelanomaLife with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficienciesRole of α7 nicotinic receptor in the immune system and intracellular signaling pathwaysGone to Pot - A Review of the Association between Cannabis and PsychosisHigh resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibitionBinding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational changePhosphatidylinositol 3-kinase mutations identified in human cancer are oncogenicA role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental healthAkt2 negatively regulates assembly of the POSH-MLK-JNK signaling complexThe Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIPIdentification of 14-3-3zeta as a protein kinase B/Akt substrateNegative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survivalMolecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivoDopamine receptors - IUPHAR Review 13Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale.Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificityAdoptive transfer of heme oxygenase-1 (HO-1)-modified macrophages rescues the nuclear factor erythroid 2-related factor (Nrf2) antiinflammatory phenotype in liver ischemia/reperfusion injuryThyroid hormone T3 counteracts STZ induced diabetes in mouseOverexpression of Akt1 enhances adipogenesis and leads to lipoma formation in zebrafishRole for Akt3/protein kinase Bgamma in attainment of normal brain sizeAbnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse modelB Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA ProcessingThe pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertImpaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermisMultiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase BTargeting the phosphoinositide 3-kinase pathway in cancerAkt regulates growth by directly phosphorylating Tsc2PfPKB, a protein kinase B-like enzyme from Plasmodium falciparum: II. Identification of calcium/calmodulin as its upstream activator and dissection of a novel signaling pathwayPfPKB, a novel protein kinase B-like enzyme from Plasmodium falciparum: I. Identification, characterization, and possible role in parasite developmentAll Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.Pregnenolone sulfate normalizes schizophrenia-like behaviors in dopamine transporter knockout mice through the AKT/GSK3β pathway.PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse.Control of the segmentation process by graded MAPK/ERK activation in the chick embryo.Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis.Akt signaling regulates side population cell phenotype via Bcrp1 translocation.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
PKB/AKT: functional insights from genetic models.
@ast
PKB/AKT: functional insights from genetic models.
@en
PKB/AKT: functional insights from genetic models.
@nl
type
label
PKB/AKT: functional insights from genetic models.
@ast
PKB/AKT: functional insights from genetic models.
@en
PKB/AKT: functional insights from genetic models.
@nl
prefLabel
PKB/AKT: functional insights from genetic models.
@ast
PKB/AKT: functional insights from genetic models.
@en
PKB/AKT: functional insights from genetic models.
@nl
P356
P1476
PKB/AKT: functional insights from genetic models.
@en
P2093
J R Woodgett
M P Scheid
P2888
P304
P356
10.1038/35096067
P577
2001-10-01T00:00:00Z
P5875
P6179
1047571972