Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
about
Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaEpimutational profile of hematologic malignancies as attractive target for new epigenetic therapiesTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesPolycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular backgroundTargeting histone methyltransferases and demethylases in clinical trials for cancer therapyDNA Methylation and Chromatin Remodeling: The Blueprint of Cancer EpigeneticsTargeting EZH2 in cancerEZH2 in normal hematopoiesis and hematological malignanciesMutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomasGenetics of myeloproliferative neoplasmsChemical probes of histone lysine methyltransferasesEpigenomics of cancer - emerging new conceptsThe epigenetic basis of diffuse large B-cell lymphomaMechanisms of epigenetic regulation of leukemia onset and progressionRecent progress toward epigenetic therapies: the example of mixed lineage leukemiaHistone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and preventionCancer epigenetics drug discovery and development: the challenge of hitting the markChromatin signatures of cancerGain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic interventionPolycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Chemogenetic analysis of human protein methyltransferasesStructure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic MutationsA selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL modelsTargeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genesEmerging concepts of epigenetic dysregulation in hematological malignanciesSynthetic reversal of epigenetic silencingDeazaneplanocin a is a promising drug to kill multiple myeloma cells in their nicheEZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomasEZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and LymphomagenesisMutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In VitroOccupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutEZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutationsDisruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity.Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.Epigenetic control of immunityEZH2 alterations in follicular lymphoma: biological and clinical correlations.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
P2860
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P2860
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@ast
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@en
Coordinated activities of wild ...... ion of lysine 27 on histone H3
@nl
type
label
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@ast
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@en
Coordinated activities of wild ...... ion of lysine 27 on histone H3
@nl
prefLabel
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@ast
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@en
Coordinated activities of wild ...... ion of lysine 27 on histone H3
@nl
P2093
P2860
P356
P1476
Coordinated activities of wild ...... 27) in human B-cell lymphomas.
@en
P2093
Christopher J Sneeringer
Kevin W Kuntz
Margaret Porter Scott
Robert A Copeland
Roy M Pollock
Sarah K Knutson
Victoria M Richon
P2860
P304
20980-20985
P356
10.1073/PNAS.1012525107
P407
P577
2010-11-15T00:00:00Z