Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein.
about
Anesthesiology physician scientists in academic medicine: a wake-up callAnesthetic modulation of protein dynamics: insight from an NMR studyCrystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systemsA Unitary Anesthetic Binding Site at High ResolutionStructural and Functional Characterization of an Anesthetic Binding Site in the Second Cysteine-Rich Domain of Protein Kinase Cδ∗Ferritin couples iron and fatty acid metabolismBeyond the detergent effect: a binding site for sodium dodecyl sulfate (SDS) in mammalian apoferritinChiral Alkyl Halides: Underexplored Motifs in MedicineThe Halogen BondA high-throughput approach for identification of novel general anestheticsIsoflurane's Effect on Protein Conformation as a Proposed Mechanism for PreconditioningIs conformation a fundamental descriptor in QSAR? A case for halogenated anestheticsFunctional group/guild modelling of inter-specific pathogen interactions: a potential tool for predicting the consequences of co-infection.The Molecular Mechanisms of Anesthetic Action: Updates and Cutting Edge Developments from the Field of Molecular Modeling.Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel.Chapter 4. Predicting and characterizing protein functions through matching geometric and evolutionary patterns of binding surfaces.Unresponsive correlated motion in alpha7 nAChR to halothane binding explains its functional insensitivity to volatile anesthetics.Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.Anesthetic binding in a pentameric ligand-gated ion channel: GLICRecognition of anesthetic barbiturates by a protein binding site: a high resolution structural analysis.Characterization of a computationally designed water-soluble human μ-opioid receptor variant using available structural informationGeneral anesthetics predicted to block the GLIC pore with micromolar affinity.Molecular approaches to improving general anestheticsVolatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties.Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics.Isoflurane increases neuronal cell death vulnerability by downregulating miR-214.Anesthetic drug development: Novel drugs and new approaches.Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundlesPrediction of volatile anesthetic binding sites in proteins.Shaping quaternary assemblies of water-soluble non-peptide helical foldamers by sequence manipulation.Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC.Sevoflurane impairs acquisition learning and memory function in transgenic mice model of Alzheimer's disease by induction of hippocampal neuron apoptosisThe volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavityRole for the propofol hydroxyl in anesthetic protein target molecular recognition.Identification of a fluorescent general anesthetic, 1-aminoanthracene.Mechanism of interaction between the general anesthetic halothane and a model ion channel protein, I: Structural investigations via X-ray reflectivity from Langmuir monolayersA Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes.Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1.General anesthetic binding to neuronal alpha4beta2 nicotinic acetylcholine receptor and its effects on global dynamicsSevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1.
P2860
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P2860
Structural basis for high-affinity volatile anesthetic binding in a natural 4-helix bundle protein.
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Structural basis for high-affi ...... atural 4-helix bundle protein.
@ast
Structural basis for high-affi ...... atural 4-helix bundle protein.
@en
Structural basis for high-affi ...... atural 4-helix bundle protein.
@nl
type
label
Structural basis for high-affi ...... atural 4-helix bundle protein.
@ast
Structural basis for high-affi ...... atural 4-helix bundle protein.
@en
Structural basis for high-affi ...... atural 4-helix bundle protein.
@nl
prefLabel
Structural basis for high-affi ...... atural 4-helix bundle protein.
@ast
Structural basis for high-affi ...... atural 4-helix bundle protein.
@en
Structural basis for high-affi ...... atural 4-helix bundle protein.
@nl
P2093
P356
P1433
P1476
Structural basis for high-affi ...... atural 4-helix bundle protein.
@en
P2093
Patrick J Loll
Roderic G Eckenhoff
P304
P356
10.1096/FJ.04-3171COM
P407
P577
2005-04-01T00:00:00Z