Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites - Wikidata - awgldk - TriplyDB

Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites

Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites

http://www.wikidata.org/entity/Q34408886

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Platform for Plasmodium vivax vaccine discovery and development Prolonged antigen presentation is required for optimal CD8+ T cell responses against malaria liver stage parasites Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation.Immunization with radiation-attenuated Plasmodium berghei sporozoites induces liver cCD8alpha+DC that activate CD8+T cells against liver-stage malaria.Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria Vaccine Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells.Short-term antigen presentation and single clonal burst limit the magnitude of the CD8(+) T cell responses to malaria liver stages.CSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytes Malaria and the liver: immunological hide-and-seek or subversion of immunity from within?Early transcriptional responses of HepG2-A16 liver cells to infection by Plasmodium falciparum sporozoites Exoerythrocytic malaria vaccine development: understanding host-parasite immunobiology underscores strategic success.Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver Inhibition of nitric oxide interrupts the accumulation of CD8+ T cells surrounding Plasmodium berghei-infected hepatocytes.Genetically attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells Malaria vaccines in development.Transformation of sporozoites into early exoerythrocytic malaria parasites does not require host cells Pre-erythrocytic malaria vaccines: towards greater efficacy.A combined transcriptome and proteome survey of malaria parasite liver stages.Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria.Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice.Not all CD4+ memory T cells are long lived.Vaccination against malaria with live parasites.Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria.Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells.Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem Genetically engineered, attenuated whole-cell vaccine approaches for malaria.The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.Diversity covering AMA1-MSP119 fusion proteins as malaria vaccines.Antigens for pre-erythrocytic malaria vaccines: building on success.Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity.Cell biology and immunology of malaria.HIF-1α induction, proliferation and glycolysis of Theileria-infected leukocytes.Immunity to malaria in an era of declining malaria transmission.Immunogenicity of four Plasmodium falciparum preerythrocytic antigens in Aotus lemurinus monkeys.Protective immunity differs between routes of administration of attenuated malaria parasites independent of parasite liver load.Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides.

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Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites

http://www.wikidata.org/entity/Q34408886

description

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Proceedings of the National Academy of Sciences of the United States of America

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Maintenance of protective immu ...... ed from irradiated sporozoites

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Azad AF

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Susceptibility of different strains of mice to hepatic infection with Plasmodium berghei.

Safety, immunogenicity, and efficacy of a Plasmodium falciparum vaccine comprising a circumsporozoite protein repeat region peptide conjugated to Pseudomonas aeruginosa toxin A.

Rapid, large-scale isolation of Plasmodium berghei sporozoites from infected mosquitoes.

Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells.

Comparative studies on the immunogenicity of infective and attenuated sporozoites of Plasmodium berghei.

The chemotherapy of rodent malaria. LI. Studies on a new 8-aminoquinoline, WR 238,605.

Long-term persistence of sterile immunity in a volunteer immunized with X-irradiated Plasmodium falciparum sporozoites.

Generation of chromosome size polymorphism during in vivo mitotic multiplication of Plasmodium berghei involves both loss and addition of subtelomeric repeat sequences.

Detection of different developmental stages of malaria parasites by non-radioactive DNA in situ hybridization.

Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development.

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