Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells.
about
Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+ T cell release of IFN-gammaIn vivo CD8+ T cell dynamics in the liver of Plasmodium yoelii immunized and infected miceMalaria: progress, perils, and prospects for eradicationThe Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial ParasitesA sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage developmentProtective immunity to liver-stage malariaPlasmodium cellular effector mechanisms and the hepatic microenvironmentTowards genome-wide experimental genetics in the in vivo malaria model parasite Plasmodium bergheiPreerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by designInactivation of a Plasmodium apicoplast protein attenuates formation of liver merozoitesConserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoitesImmunization with radiation-attenuated Plasmodium berghei sporozoites induces liver cCD8alpha+DC that activate CD8+T cells against liver-stage malaria.Sterile protection against Plasmodium knowlesi in rhesus monkeys from a malaria vaccine: comparison of heterologous prime boost strategies.Phenotypic characterization of Plasmodium berghei responsive CD8+ T cells after immunization with live sporozoites under chloroquine coverWhy functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model.Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.Engineering of Genetically Arrested Parasites (GAPs) For a Precision Malaria VaccineIdentification of pre-erythrocytic malaria antigens that target hepatocytes for killing in vivo and contribute to protection elicited by whole-parasite vaccination.Differential effector pathways regulate memory CD8 T cell immunity against Plasmodium berghei versus P. yoelii sporozoites.Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory.Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.Advances and challenges in malaria vaccine development.Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells.Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malariaAPC licensing and CD4+T cell help in liver-stage malariaCSP--a model for in vivo presentation of Plasmodium berghei sporozoite antigens by hepatocytesMalaria Parasite Liver Infection and Exoerythrocytic Biology.A phase Ia study to assess the safety and immunogenicity of new malaria vaccine candidates ChAd63 CS administered alone and with MVA CS.Plasmodium-host interactions directly influence the threshold of memory CD8 T cells required for protective immunityDynamics of the major histocompatibility complex class I processing and presentation pathway in the course of malaria parasite development in human hepatocytes: implications for vaccine development.Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasitesCD40 is required for protective immunity against liver stage Plasmodium infectionStudying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malariaImmunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liverAAV8-mediated in vivo overexpression of miR-155 enhances the protective capacity of genetically attenuated malarial parasitesMechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites.A Sporozoite- and Liver Stage-expressed Tryptophan-rich Protein Plays an Auxiliary Role in Plasmodium Liver Stage Development and Is a Potential Vaccine Candidate.Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria.Chemical attenuation of Plasmodium berghei sporozoites induces sterile immunity in mice.Effector CD8+ T lymphocytes against liver stages of Plasmodium yoelii do not require gamma interferon for antiparasite activity.
P2860
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P2860
Genetically attenuated Plasmodium berghei liver stages induce sterile protracted protection that is mediated by major histocompatibility complex Class I-dependent interferon-gamma-producing CD8+ T cells.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@ast
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@en
type
label
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@ast
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@en
prefLabel
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@ast
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@en
P2093
P2860
P356
P1476
Genetically attenuated Plasmod ...... -gamma-producing CD8+ T cells.
@en
P2093
Ann-Kristin Mueller
Hilda Silva-Rivera
Jackie Williams
Joanne Lumsden
Ousman Jobe
Robert J Schwenk
Urszula Krzych
P2860
P304
P356
10.1086/519743
P407
P577
2007-07-09T00:00:00Z